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Current Hypertension Reports

, 19:72 | Cite as

Effects of RAAS Inhibitors in Patients with Kidney Disease

  • Fan Zhang
  • Hong LiuEmail author
  • Di Liu
  • Yexin Liu
  • Huiqiong Li
  • Xia Tan
  • Fuyou Liu
  • Youming Peng
  • Hongqing Zhang
Hypertension and the Kidney (RM Carey, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Hypertension and the Kidney

Abstract

Proteinuria and decline of renal function are associated with progression of kidney disease. The Renin Angiotensin Aldosterone System (RAAS) plays an important role in blood pressure regulation, fluid volume, and sodium balance. Overactivity of RAAS contributes to the pathogenesis of a variety of clinical conditions including progress of chronic kidney disease (CKD). This review summarizes the use of RAAS inhibitors as dual therapy or monotherapy in different stages of kidney disease. Experimental and clinical studies have demonstrated RAAS inhibitors prevent proteinuria, kidney fibrosis and slow decline of renal function and thus play a protective role in both early and end stages of kidney disease. While combination use of RAAS inhibitors showed higher efficiency compared with monotherapy, it is also associated with higher incidence of adverse events. Besides ACEI/ARBs, more mechanism research of mineralocorticoid receptor antagonists in kidney disease should be performed.

Keywords

Renin Angiotensin Aldosterone System RAAS RAAS inhibitors Chronic kidney disease Proteinuria 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Fan Zhang
    • 1
  • Hong Liu
    • 1
    Email author
  • Di Liu
    • 1
  • Yexin Liu
    • 1
  • Huiqiong Li
    • 1
  • Xia Tan
    • 1
  • Fuyou Liu
    • 1
  • Youming Peng
    • 1
  • Hongqing Zhang
    • 1
  1. 1.Department of NephrologyThe Second Xiangya Hospital of Central South University, Renal Research Institute of Central South University, Key Lab of Kidney Disease and Blood Purification in HunanChangshaChina

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