Antihypertensive Therapies and Cognitive Function: a Review

  • Nisharahmed Kherada
  • Todd Heimowitz
  • Clive Rosendorff
Hypertension and the Brain (S Stocker, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Hypertension and the Brain


Increasing life expectancy has made old age-related health problems like dementia and cognitive decline more prevalent, and these are rapidly becoming important causes of disability and poor quality of life, causing significant add-ons to health-care costs worldwide. Hypertension is the most important modifiable vascular risk factor for the development and progression of both cognitive decline and dementia. In many observational and randomized studies, antihypertensive therapies have been shown to be beneficial in slowing cognitive decline. However, due to observed discrepancies by these studies, there is a lack of consensus on the best antihypertensive strategy for the prevention or slowing of cognitive decline. It is also not clear whether the beneficial effect of antihypertensive therapy is due to the use of a specific class of agents or combination therapy. Thus, we present a comprehensive review of overall antihypertensive therapies and cognition and of the individual antihypertensive therapy classes with their specific protective mechanisms and available clinical evidence behind their effect on cognitive function.


Dementia Cognition Alzheimer’s disease Stroke Antihypertensive therapies 


Compliance with Ethics Guidelines

Conflict of Interest

Dr. Kherada, Dr. Heimowitz, and Dr. Rosendorff declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Nisharahmed Kherada
    • 1
  • Todd Heimowitz
    • 1
  • Clive Rosendorff
    • 2
  1. 1.Department of Cardiology, Mount Sinai Medical CenterColumbia UniversityMiami BeachUSA
  2. 2.Department of Cardiology, James J. Peters VA Medical CenterIcahn School of Medicine at Mount SinaiBronxUSA

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