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Current Hypertension Reports

, 16:497 | Cite as

The Thrill of Success: Central Arterial-Venous Anastomosis for Hypertension

  • Marat Fudim
  • Alice Stanton
  • Paul A. Sobotka
  • Eamon Dolan
  • Henry Krum
Device-Based Approaches for Hypertension (M Schlaich, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Device-Based Approaches for Hypertension

Abstract

Excess blood pressure remains the most important risk factor for cardiovascular and renal disease. Poly pharmacy has been proved safe and effective under clinical trial circumstances; however, the majority of patients fail to sustain pharmaceutical persistence and adherence. The opportunity to offer patients a treatment or device in addition or perhaps instead of drug therapy alone may significantly broaden the options for patients and allow greater success in hypertensive therapy. In this review, we examine the potential of a fixed-volume central arterial-venous anastomosis to reduce blood pressure in hypertensive patients, review possible mechanisms by which the anastomosis may reduce blood pressure, and consider the unique clinical trial opportunities posed by this therapy.

Keywords

Venous circulation Blood volume Shunt Chemoreceptorsl Cardio-pulmonary reflexes Hypertension 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Alice Stanton, Eamon Dolan, and Henry Krum declare no conflict of interest. Marat Fudim is a consultant for Cibiem, Inc. Paul A. Sobotka is a consultant for Abbott Ventures, Ardian, Boston Scientific, Medtronic, Nephera, and Ardelyx and is Chief Medical Officer for Cibiem and Rox Medical.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Marat Fudim
    • 1
  • Alice Stanton
    • 2
  • Paul A. Sobotka
    • 3
  • Eamon Dolan
    • 2
  • Henry Krum
    • 4
  1. 1.Vanderbilt UniversityNashvilleUSA
  2. 2.Royal College of Surgeons in IrelandDublinIreland
  3. 3.ROX Medical Inc., The Ohio State UniversitySt PaulUSA
  4. 4.Monash University, Alfred HospitalMelbourneAustralia

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