Current Hypertension Reports

, 16:468

Blood Pressure in Relation to Coffee and Caffeine Consumption

Blood Pressure Monitoring and Management (G Ogedegbe and JA Staessen, Section Editors)

DOI: 10.1007/s11906-014-0468-2

Cite this article as:
Guessous, I., Eap, C.B. & Bochud, M. Curr Hypertens Rep (2014) 16: 468. doi:10.1007/s11906-014-0468-2
Part of the following topical collections:
  1. Topical Collection on Blood Pressure Monitoring and Management


The relationship between blood pressure (BP) and coffee is of major interest given its widespread consumption and the public health burden of high BP. Yet, there is no specific recommendation regarding coffee intake in existing hypertension guidelines. The lack of a definitive understanding of the BP-coffee relationship is partially attributable to issues that we discuss in this review, issues such as acute vs. chronic effects, genetic and smoking effect modifications, and coffee vs. caffeine effects. We also present evidence from meta-analyses of studies on the association of BP with coffee intake. The scope of this review is limited to the latest advances published with a specific focus on caffeine, acknowledging that caffeine is only one among numerous components in coffee that may influence BP. Finally, considering the state of the research, we propose a mechanism by which the CYP1A2 gene and enzyme influence BP via inhibition of the adenosine receptor differentially in smokers and non-smokers.


Blood pressure Hypertension Coffee Caffeine CYP1A2 Genetics Enzyme Smoking Adenosine Renal sodium reabsorption 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Idris Guessous
    • 1
    • 2
  • Chin B. Eap
    • 3
    • 4
  • Murielle Bochud
    • 2
  1. 1.Unit of Population Epidemiology, Department of Community Medicine and Primary Care and Emergency MedicineUniversity Hospital of GenevaGenevaSwitzerland
  2. 2.Institute of Social and Preventive Medicine (IUMSP)Lausanne University HospitalLausanneSwitzerland
  3. 3.Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, Department of PsychiatryCentre Hospitalier Universitaire Vaudois, University of Lausanne, Hospital of CeryLausanneSwitzerland
  4. 4.School of Pharmaceutical Sciences, University of Geneva, University of LausanneLausanneSwitzerland

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