Sleep Disturbances and Resistant Hypertension: Association or Causality?

  • Daniel Castanho Genta-Pereira
  • Rodrigo P. Pedrosa
  • Geraldo Lorenzi-Filho
  • Luciano F. DragerEmail author
Resistant Hypertension (E Pimenta, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Resistant Hypertension


Two main sleep disturbances, namely obstructive sleep apnea (OSA) and sleep deprivation, have gained growing interest in the field of hypertension research. This fact is supported not only by evidence that both disturbances are quite common in modern societies but also that OSA and sleep deprivation are associated with several pathways that may contribute to a predisposition to hypertension or even exacerbate blood pressure levels in hypertensive patients. In the present review, we will discuss current evidence supporting a potential role of these sleep disturbances in the resistant hypertension scenario.


Cardiovascular risk Hypertension Sleep apnea Sleep deprivation Sleep disturbances 


Compliance with Ethics Guidelines

Conflict of Interest Daniel Castanho Genta-Pereira, Rodrigo P. Pedrosa, Geraldo Lorenzi-Filho, and Luciano F. Drager declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Daniel Castanho Genta-Pereira
    • 1
  • Rodrigo P. Pedrosa
    • 2
  • Geraldo Lorenzi-Filho
    • 3
  • Luciano F. Drager
    • 1
    • 4
    Email author
  1. 1.Hypertension Unit, Heart Institute (InCor)University of São Paulo Medical SchoolSão PauloBrazil
  2. 2.Sleep and Heart LaboratoryPronto Socorro Cardiológico de Pernambuco (PROCAPE) da Universidade de PernambucoRecifeBrazil
  3. 3.Sleep Laboratory, Pulmonary Division, Heart Institute (InCor)University of São Paulo Medical SchoolSão PauloBrazil
  4. 4.Hypertension Unit, Nephrology DivisionUniversity of São Paulo Medical SchoolSão PauloBrazil

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