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Fructose and Uric Acid: Is There a Role in Endothelial Function?

  • Guanghong Jia
  • Annayya R. Aroor
  • Adam T. Whaley-Connell
  • James R. SowersEmail author
Hypertension and Metabolic Syndrome (JR Sowers and AT Whaley-Connell, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Hypertension and Metabolic Syndrome

Abstract

Population level data support that consumption of fructose and fructose-based sweeteners has dramatically increased and suggest that high dietary intake of fructose is an important factor in the development of the cardiorenal metabolic syndrome (CRS). The CRS is a constellation of cardiac, kidney and metabolic disorders including insulin resistance, obesity, metabolic dyslipidemia, high blood pressure, and evidence of early cardiac and kidney disease. The consequences of fructose metabolism may result in intracellular ATP depletion, increased uric acid production, oxidative stress, inflammation, and increased lipogenesis, which are associated with endothelial dysfunction. Endothelial dysfunction is an early manifestation of vascular disease and a driver for the development of CRS. A better understanding of fructose overconsumption in the development of CRS may provide new insights into pathogenesis and future therapeutic strategies.

Keywords

Cardiorenal metabolic syndrome Nitric oxide Lipogenesis Insulin resistance Hypertension Oxidative stress Inflammation Estrogen 

Notes

Acknowledgments

The authors would like to thank Brenda Hunter for her editorial assistance. This research was supported by National Institutes of Health grants HL-73101 and HL-107910 to J.R.S. and AG-040638 to A.W.-C. and the Veterans Affairs Merit System 0018 (J.R.S.) and CDA-2 (A.W.-C.).

Compliance with Ethics Guidelines

Conflict of Interest Guanghong Jia, Annayya R. Aroor, Adam T. Whaley-Connell, and James R. Sowers declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Guanghong Jia
    • 1
    • 3
    • 5
  • Annayya R. Aroor
    • 1
    • 3
    • 5
  • Adam T. Whaley-Connell
    • 1
    • 2
    • 3
    • 5
  • James R. Sowers
    • 1
    • 3
    • 4
    • 5
    Email author
  1. 1.Division of Endocrinology and Metabolism, Department of MedicineUniversity of Missouri School of MedicineColumbiaUSA
  2. 2.Division of Nephrology and Hypertension, Department of MedicineUniversity of Missouri School of MedicineColumbiaUSA
  3. 3.Research Service Harry S Truman Memorial Veterans Hospital, Research ServiceColumbiaUSA
  4. 4.Department of Medical Pharmacology and PhysiologyUniversity of Missouri School of MedicineColumbiaUSA
  5. 5.Diabetes and Cardiovascular CenterUniversity of Missouri School of MedicineColumbiaUSA

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