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Current Hypertension Reports

, 16:415 | Cite as

Corin in Natriuretic Peptide Processing and Hypertension

  • Yiqing Zhou
  • Qingyu WuEmail author
Mediators, Mechanisms, and Pathways in Tissue Injury (T Fujita, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Mediators, Mechanisms, and Pathways in Tissue Injury

Abstract

Corin is a serine protease originally isolated from the heart. Functional studies show that corin is the long-sought enzyme responsible for activating cardiac natriuretic peptides. In mice, lack of corin prevents natriuretic peptide processing, causing salt-sensitive hypertension. In humans, corin variants and mutations that reduce corin activity have been identified in patients with hypertension and heart failure. Decreased plasma levels of corin antigen and activity have been reported in patients with heart failure and coronary artery disease. Low levels of urinary corin also have been found in patients with chronic kidney disease. Most recent studies show that corin also acts in the uterus to promote spiral artery remodeling and prevent pregnancy-induced hypertension. Here, we review the role of corin in natriuretic peptide processing and cardiovascular diseases such as hypertension, heart disease, pre-eclampsia, and chronic kidney disease.

Keywords

African American ANP BNP Cardiac hypertrophy Chronic kidney disease CNP Corin ENaC Gene mutation Gene variant Heart failure Hypertension Natriuretic peptides Pre-eclampsia Salt-sensitive hypertension Spiral artery remodeling Trophoblast invasion 

Notes

Acknowledgments

We would like to thank our co-workers, past and present, who contributed to corin studies. This work was supported in part by NIH grants R01 HL089298 and HD064634, and grants from the National Natural Science Foundation of China (31070716, 81170247 and 31161130356) and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.

Compliance with Ethics Guidelines

Conflict of Interest

Yiqing Zhou and Qingyu Wu declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated HospitalSoochow UniversitySuzhouChina
  2. 2.Departments of Molecular CardiologyLerner Research Institute, Cleveland ClinicClevelandUSA
  3. 3.Molecular CardiologyCleveland ClinicClevelandUSA

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