Current Hypertension Reports

, Volume 15, Issue 3, pp 175–181 | Cite as

Potential Role of Uric Acid in Metabolic Syndrome, Hypertension, Kidney Injury, and Cardiovascular Diseases: Is It Time for Reappraisal?

  • Zohreh SoltaniEmail author
  • Kashaf Rasheed
  • Daniel R. Kapusta
  • Efrain Reisin
Hypertension and Obesity (E Reisin, Section Editor)


Elevated serum uric acid concentration is a common laboratory finding in subjects with metabolic syndrome/obesity, hypertension, kidney disease and cardiovascular events. Hyperuricemia has been attributed to hyperinsulinemia in metabolic syndrome and to decreased uric acid excretion in kidney dysfunction, and is not acknowledged as a main mediator of metabolic syndrome, renal disease, and cardiovascular disorder development. However, more recent investigations have altered this traditional view and shown, by providing compelling evidence, to support an independent link between hyperuricemia and increased risk of metabolic syndrome, diabetes, hypertension, kidney disease and cardiovascular disorders. However, despite these new findings, controversy regarding the exact role of uric acid in inducing these diseases remains to be unfolded. Furthermore, recent data suggest that the high-fructose diet in the United State, as a major cause of hyperuricemia, may be contributing to the metabolic syndrome/obesity epidemic, diabetes, hypertension, kidney disease and cardiovascular disorder. Our focus in this review is to discuss the available evidence supporting a role for uric acid in the development of metabolic syndrome, hypertension, renal disease, and cardiovascular disorder; and the potential pathophysiology mechanisms involved.


Uric acid Hyperuricemia Fructose Metabolic syndrome Obesity Hypertension Kidney disease Cardiovascular disorder 



This work was supported by National Institutes of Health grants 8P20 GM103514 and P20 RR018766 (to Z. Soltani and D.R. Kapusta) and American Heart Association grant 12GRNT12060613 (to D.R. Kapusta).

Conflict of Interest

Z. Soltani declares that he has no conflict of interest.

Kashef Rasheed declares that he has no conflict of interest.

D.R. Kapusta declares that he has no conflict of interest.

E. Reisin declares that he has no conflict of interest.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York (outside the USA) 2013

Authors and Affiliations

  • Zohreh Soltani
    • 1
    Email author
  • Kashaf Rasheed
    • 1
  • Daniel R. Kapusta
    • 2
  • Efrain Reisin
    • 1
  1. 1.Section of Nephrology and HypertensionLouisiana State University Health Sciences CenterNew OrleansUSA
  2. 2.Department of PharmacologyLouisiana State University Health Sciences CenterNew OrleansUSA

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