Current Hypertension Reports

, Volume 15, Issue 1, pp 47–58 | Cite as

Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling

  • Robrecht Thoonen
  • Patrick Y. Sips
  • Kenneth D. Bloch
  • Emmanuel S. BuysEmail author
Hypertension and the Kidney (RM Carey and A Mimran, Section Editors)


The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for key enzymes in the NO-cGMP signaling system facilitated the identification of interactions with other blood pressure modifying pathways (e.g. the renin-angiotensin-aldosterone system) and of gender-specific effects of impaired NO-cGMP signaling. In addition, recent genome-wide association studies identified blood pressure-modifying genetic variants in genes that modulate NO and cGMP levels. Together, these findings have advanced our understanding of how NO-cGMP signaling regulates blood pressure. In this review, we will summarize the results obtained in mice with disrupted NO-cGMP signaling and highlight the relevance of this pathway as a potential therapeutic target for the treatment of hypertension.


Cyclic guanosine monophosphate Blood pressure Hypertension Cardiovascular function Soluble guanylate cyclase Nitric oxide Mutant mice Genetic variants Renin-angiotensin-aldosterone signaling Gender S-nitrosylation Therapeutics 



No potential conflicts of interest relevant to this article were reported.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Robrecht Thoonen
    • 1
  • Patrick Y. Sips
    • 2
  • Kenneth D. Bloch
    • 3
  • Emmanuel S. Buys
    • 4
    Email author
  1. 1.Molecular Cardiology Research Institute, Molecular Cardiology Research CenterTufts Medical CenterBostonUSA
  2. 2.Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General HospitalHarvard Medical SchoolCharlestownUSA
  3. 3.Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBostonUSA
  4. 4.Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General HospitalHarvard Medical SchoolBostonUSA

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