Current Hypertension Reports

, Volume 14, Issue 1, pp 29–37

Mendelian Randomization: Application to Cardiovascular Disease

  • Nicholas J. Timpson
  • Kaitlin H. Wade
  • George Davey Smith
Pathogenesis of Hypertension: Genetic and Environmental Factors (DT O’Connor, Section Editor)

DOI: 10.1007/s11906-011-0242-7

Cite this article as:
Timpson, N.J., Wade, K.H. & Smith, G.D. Curr Hypertens Rep (2012) 14: 29. doi:10.1007/s11906-011-0242-7

Abstract

In the absence of an ethical, practical, and economical randomized trial, the epidemiologist is left to explore other methods in efforts to assert causality. An approach based on genotypic variation has the potential to mitigate against some of the problems found within conventional observational studies. Genetic variations associated with risk factors of interest at the population level can be used as proxy measures for these risk factors and to generate estimates of causal effect. The potential and the possible limitations of this approach within the cardiovascular field are presented in this review.

Keywords

Cardiovascular disease Hypertension Risk factor Confounding Genetic epidemiology Causality Mendelian randomization Genetics Body mass index Lipids Lipoproteins Alcohol intake Inflammation 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Nicholas J. Timpson
    • 1
  • Kaitlin H. Wade
    • 1
  • George Davey Smith
    • 1
  1. 1.MRC CAiTE Centre, School of Social and Community MedicineBristolUK

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