Current Hypertension Reports

, Volume 13, Issue 3, pp 187–191 | Cite as

Vitamin D Therapy and Cardiovascular Health

  • Suzanne E. JuddEmail author
  • Vin Tangpricha


Vitamin D belongs to the family of nuclear steroid hormones, which has pleiotropic effects on several organ systems. Different vitamin D compounds have been studied as potential cardioprotective agents over the past 20 years. The results of these clinical studies vary based on the form and dosage of vitamin D administered during the trial. In the past 5 years, many have described an association of vitamin D compounds and cardiovascular health through reduction in blood pressure, reduction in inflammatory biomarkers, improved insulin sensitivity, and reduction in cardiovascular disease complications and death. Because there are several vitamin D compounds, it is important to consider the full breadth of the literature when examining vitamin D and cardiovascular health, to assist in hypothesis generation and understanding of the current state of the science. Although a growing body of evidence suggests that nutritional vitamin D supplementation and potentially even treatment with synthetic analogues of vitamin D may be cardioprotective, relatively few studies have examined either of these compounds in a randomized, controlled fashion. Studies examining the benefit of vitamin D supplementation are now beginning, but future studies considering calcitriol and analogue therapy also seem warranted.


Hypertension Blood pressure Clinical trials 25(OH)D Inflammation Cholecalciferol Ergocalciferol Vitamin D deficiency 



No potential conflicts of interest relevant to this article were reported.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Biostatistics, School of Public HealthUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Emory University School of MedicineAtlantaUSA
  3. 3.Staff Physician, Atlanta VA Medical CenterDecaturUSA

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