Current Hypertension Reports

, Volume 13, Issue 3, pp 244–248 | Cite as

Stress and Its Role in Sympathetic Nervous System Activation in Hypertension and the Metabolic Syndrome



Stress in several guises is evident in individuals with hypertension and in those with the metabolic syndrome and may account, at least in part, for the extent and pattern of sympathetic nervous activation. Importantly, elevated activity of the sympathetic nervous system is related to the development of obesity-related illnesses including hypertension, insulin resistance, and renal, cardiac, and vascular impairment. Notably, evidence of subclinical organ damage is evident even in young, normotensive, overweight persons, thereby reinforcing the need to develop and implement effective early intervention.


Stress Sympathetic nervous system Obesity Metabolic syndrome 



This work was supported by grants from the National Health and Medical Research Council of Australia (NHMRC).


The investigators (or their laboratory) have received research funding from commercial sponsors including Abbot (formerly Solvay Pharmaceuticals), Servier, Ardian Inc, Allergan, and Scientific Intake. Dr. Gavin Lambert has received honoraria or travel support for presentations from Servier, Wyeth Pharmaceuticals, and Pfizer. No other potential conflicts of interest relevant to this article were reported.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Human Neurotransmitters LaboratoryBaker IDI Heart & Diabetes InstituteMelbourneAustralia

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