Abstract
In our consumer-oriented society, in which productivity requires around-the-clock activity and demanding shift work, the biologic system that regulates our internal rhythms is being compromised. Poor sleep patterns and hectic lifestyle are detrimental to harmonious physiological and metabolic body systems, with severe impact on public health. Over a trillion peripheral cellular clocks throughout the body, supervised by the master clock located in the hypothalamic suprachiasmatic nucleus, govern most aspects of physiology and behavior. To exemplify the importance of the biologic clock for health, we have recently demonstrated that mice that are arrhythmic because of the deletion of Cry1 and Cry2 clock genes suffer from salt-sensitive hypertension. In these mice, a novel 3β-hydroxyl-steroid dehydrogenase (3β–Hsd) gene under clock control is severely overexpressed specifically in aldosterone-producing cells in the adrenal cortex, leading to hyperaldosteronism and ultimately to salt-sensitive hypertension. The human homologue of this aldosterone-producing, cell-specific enzyme was also characterized and represents a new possibility in the pathogenesis of hypertension.
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Acknowledgments
The research from our laboratory reported in this review was supported by grants from the Special Coordination Funds and a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and from Health Labour Sciences Research Grant Research on Measures for Intractable Diseases from The Ministry of Health, Labour and Welfare, Japan.
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Okamura, H., Doi, M., Yamaguchi, Y. et al. Hypertension Due to Loss of Clock: Novel Insight From the Molecular Analysis of Cry1/Cry2–Deleted Mice. Curr Hypertens Rep 13, 103–108 (2011). https://doi.org/10.1007/s11906-011-0181-3
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DOI: https://doi.org/10.1007/s11906-011-0181-3