Current Hypertension Reports

, Volume 12, Issue 5, pp 335–341

Chronic Kidney Disease and Albuminuria in Arterial Hypertension

  • Giovanna Leoncini
  • Francesca Viazzi
  • Roberto Pontremoli
Article

DOI: 10.1007/s11906-010-0141-3

Cite this article as:
Leoncini, G., Viazzi, F. & Pontremoli, R. Curr Hypertens Rep (2010) 12: 335. doi:10.1007/s11906-010-0141-3

Abstract

Chronic kidney disease is a major public health problem worldwide: it is estimated that in the general population, 1 person in 10 has some degree of renal damage. Adequate blood pressure control represents the mainstay of treatment, to delay deterioration of renal function and prevent cardiovascular complications. Current evidence supports a target blood pressure value of 130/80 mm Hg or less (ie, <125/75 mm Hg) when proteinuria exceeds 1 g/L. Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers represent the treatment of choice, especially in the presence of proteinuria. More complete blockade of the renin-angiotensin-aldosterone system (RAAS) has been advocated, using a combination of multiple RAAS blocker drugs or supramaximal doses to maximize renal protection. Achieving recommended blood pressure target values usually requires the use of multiple antihypertensive drugs, including diuretics and calcium channel blockers.

Keywords

Angiotensin-converting enzyme inhibitors ACE inhibitors ACE-I Angiotensin II receptor blockers ARB Antihypertensive treatment Chronic kidney disease Hypertension Progression Proteinuria Renal protection Renin-angiotensin-aldosterone system RAAS 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Giovanna Leoncini
    • 1
  • Francesca Viazzi
    • 1
  • Roberto Pontremoli
    • 1
  1. 1.Department of Cardionephrology and Department of Internal MedicineUniversity of GenoaGenoaItaly

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