Current Hypertension Reports

, Volume 11, Issue 1, pp 63–68

Angiotensin vaccination: What is the prospect of success?

Article

DOI: 10.1007/s11906-009-0012-y

Cite this article as:
Campbell, D.J. Current Science Inc (2009) 11: 63. doi:10.1007/s11906-009-0012-y

Abstract

Over many decades, several attempts have been made to treat hypertension using a vaccination strategy to inhibit the renin-angiotensin system. Renin vaccination successfully inhibited renin activity and reduced blood pressure in animal models, but caused autoimmune disease of the kidney. By contrast, most previous studies of angiotensin vaccination failed to reduce blood pressure in animal models, despite producing high titers of antibodies that prevented the pressor response to exogenous angiotensins. Angiotensin vaccination is being revisited as a strategy for treating hypertension, in the hope that new conjugates of angiotensin I and angiotensin II will produce antibodies of sufficient titer and affinity to reduce blood pressure in patients with hypertension. A recent clinical study of angiotensin II vaccination provided some cause for optimism, but many hurdles remain before this strategy can compete with current oral medications for hypertension.

Copyright information

© Current Medicine Group LLC 2009

Authors and Affiliations

  1. 1.St. Vincent’s Institute of Medical ResearchFitzroyAustralia

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