Current Hypertension Reports

, Volume 10, Issue 2, pp 107–111 | Cite as

Arterial structure and function in end-stage renal disease

  • Alain P. Guérin
  • Bruno Pannier
  • Sylvain J. Marchais
  • Gérard M. LondonEmail author


Cardiovascular disease is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Macrovascular disease develops rapidly in ESRD patients and is responsible for the high incidence of left ventricular hypertrophy, ischemic heart disease, cerebrovascular accidents, and peripheral artery diseases. Occlusive lesions due to atheromatous plaques frequently cause these complications; however, atherosclerosis represents only one form of structural response to metabolic and hemodynamic alterations interfering with the “natural” process of aging. The spectrum of arterial alterations in ESRD is broader, including large artery remodeling, changes in viscoelastic properties, and stiffening of arterial walls. Nonatheromatous remodeling principally changes the dampening function of arteries, characterized by stiffening of arterial walls and with deleterious effects on the left ventricle and coronary perfusion. The origin of arterial stiffening in ESRD patients is multifactorial, with extensive arterial calcifications as an important covariate.


Chronic Kidney Disease Arterial Wall Arterial Stiffening Pulse Wave Velocity Aortic Stiffness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  • Alain P. Guérin
  • Bruno Pannier
  • Sylvain J. Marchais
  • Gérard M. London
    • 1
    Email author
  1. 1.Hôpital ManhèsFleury-MérogisFrance

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