Agonist autoantibodies against the angiotensin AT1 receptor in renal and hypertensive disorders
- First Online:
- 67 Downloads
Previous studies demonstrated the significance of an agonistic angiotensin II receptor AT1 autoantibody (AT1-AA) in preeclampsia. Because of its ability to release calcium in vascular smooth muscle cells, stimulate reactive oxygen species, and initiate proinflammatory processes, this antibody was thought to be important in the etiology and pathogenesis of preeclampsia. Recent investigations, however, have broadened and refined the pathobiological relevance of this antibody and refuted its role as the primary cause for preeclampsia. Because AT1-AA has been linked to an impaired uteroplacental perfusion and has been detected in patients with renal allograft rejection, its occurrence and function seem to be wider and more complex. This review summarizes current knowledge about the generation, function, and clinical importance of AT1-AA.
Unable to display preview. Download preview PDF.
References and Recommended Reading
- 14.Verlohren S, Herse F, Pijnenborg R, et al.: Agonistic autoantibodies to the AT1 receptor in rat models of preeclampsia: induced by chronic reductions in uterine perfusion pressure (RUPP) and low dose TNFalpha infusion. Geburtsh Frauenheilk 2006, 66(Suppl 1):186.Google Scholar
- 21.Chien PF, Arnott N, Gordon A, et al.: How usefu is uterine artery Doppler flow velocimetry in the prediction of preeclampsia, intrauterine growth retardation and perinatal death? An overview. Br J Obstet Gynaecol 2000, 107:196–208.Google Scholar
- 34.Stepan H, Wallukat G, Schultheiss HP, et al.: Is the parvovirus B19 the cause for autoimmunity against the angiotensin II type 1 receptor? J Reprod Immunol 2006, December 4, Epub ahead of print.Google Scholar
- 41.Zaki M, Greenwood C, Redman CW, et al.: The spontaneous reversal of pre-eclampsia associated with parvovirus-induced hydrops and the placental theory of pre-eclampsia: a case report. Br J Obstet Gynecol 2003, 110:1125–1126.Google Scholar