Current Hypertension Reports

, Volume 8, Issue 4, pp 298–303 | Cite as

Endothelin, the kidney, and hypertension

  • Joey P. Granger
  • Sean Abram
  • David Stec
  • Derrick Chandler
  • Joshua Speed
  • Babbette LaMarca


The kidneys play a central role in the long-term regulation of blood pressure and in the pathogenesis of hypertension. A common defect that has been found in all forms of hypertension examined to date is a hypertensive shift in the pressure-natriuresis relationship. A major objective of this brief review is to highlight some of the recent advances in our understanding of the mechanisms whereby the renal endothelin system, via endothelin type A- and endothelin type B-receptor activation, modulates renal pressure-natriuresis and blood pressure regulation under normal physiologic conditions and in certain forms of hypertension.


Preeclampsia Physiol Regul Integr Comp Placental Ischemia Renal Pressure Progressive Renal Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc. 2006

Authors and Affiliations

  • Joey P. Granger
    • 1
  • Sean Abram
  • David Stec
  • Derrick Chandler
  • Joshua Speed
  • Babbette LaMarca
  1. 1.Department of Physiology and BiophysicsUniversity of Mississippi Medical CenterJacksonUSA

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