Current Hypertension Reports

, Volume 6, Issue 3, pp 236–240

Leptin, sympathetic nervous system, and baroreflex function

  • Guido Grassi

DOI: 10.1007/s11906-004-0075-8

Cite this article as:
Grassi, G. Current Science Inc (2004) 6: 236. doi:10.1007/s11906-004-0075-8


In addition to its direct effects on energy metabolism and caloric intake, leptin exerts several circulatory effects that appear to be mediated by an interaction with the sympathetic nervous system and the major reflexogenic area involved in cardiovascular homeostatic control—that is, the arterial baroreflex. In this paper, the relationships between the adipocyte hormone and the neuroadrenergic function are reviewed, taking into account data collected in experimental animal models as well as in human cardiovascular (hypertension and heart failure) and noncardiovascular (obesity) diseases that are characterized by a hyperadrenergic state coupled with a hyperleptinemia.

Copyright information

© Current Science Inc 2004

Authors and Affiliations

  • Guido Grassi
    • 1
  1. 1.Clinica Medica, Ospedale San GerardoMonzaItaly

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