Current Hypertension Reports

, Volume 5, Issue 3, pp 215–220

Oxidative stress and heart disease: Cardiac dysfunction, nutrition, and gene therapy

  • Elliott J. F. Cantor
  • Enrico V. Mancini
  • Rishi Seth
  • Xing-Hai Yao
  • Thomas Netticadan
Article

Abstract

Oxidative stress is defined as the imbalance between the generation of reactive oxygen species and antioxidant defense mechanisms. The cardiovascular system is a major target for reactive oxygen species. Cardiomyocytes and the vasculature of the heart can be severely damaged as a result of oxidative stress. In this paper, we discuss recent findings with respect to the role of oxidative stress in heart disease. The efficacies of treatments with vitamins and wine-derived compounds, as well as innovative gene therapeutic experiments that may potentially alleviate oxidative stress-induced disease, are also discussed.

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Copyright information

© Current Science Inc 2003

Authors and Affiliations

  • Elliott J. F. Cantor
  • Enrico V. Mancini
  • Rishi Seth
  • Xing-Hai Yao
  • Thomas Netticadan
    • 1
  1. 1.Institute of Cardiovascular SciencesSt. Boniface General Hospital Research CentreWinnipegCanada

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