Current HIV/AIDS Reports

, Volume 12, Issue 2, pp 262–271 | Cite as

Compartmentalization, Viral Evolution, and Viral Latency of HIV in the CNS

  • Maria M. Bednar
  • Christa Buckheit Sturdevant
  • Lauren A. Tompkins
  • Kathryn Twigg Arrildt
  • Elena Dukhovlinova
  • Laura P. Kincer
  • Ronald Swanstrom
Central Nervous System and Cognition (SS Spudich, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Central Nervous System and Cognition

Abstract

Human immunodeficiency virus type 1 (HIV-1) infection occurs throughout the body and can have dramatic physical effects, such as neurocognitive impairment in the central nervous system (CNS). Furthermore, examining the virus that resides in the CNS is challenging due to its location and can only be done using samples collected either at autopsy, indirectly form the cerebral spinal fluid (CSF), or through the use of animal models. The unique milieu of the CNS fosters viral compartmentalization as well as evolution of viral sequences, allowing for new cell types, such as macrophages and microglia, to be infected. Treatment must also cross the blood–brain barrier adding additional obstacles in eliminating viral populations in the CNS. These long-lived infected cell types and treatment barriers may affect functional cure strategies in people on highly active antiretroviral therapy (HAART).

Keywords

Human immunodeficiency virus HIV Compartmentalization Tropism Latency Evolution Eradication CNS CSF Animal models 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Maria M. Bednar
    • 1
  • Christa Buckheit Sturdevant
    • 2
  • Lauren A. Tompkins
    • 3
  • Kathryn Twigg Arrildt
    • 3
  • Elena Dukhovlinova
    • 1
  • Laura P. Kincer
    • 1
  • Ronald Swanstrom
    • 1
    • 3
    • 4
  1. 1.Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel HillChapel HillUSA
  2. 2.Department of SurgeryDuke University Medical CenterDurhamUSA
  3. 3.Department of Microbiology and ImmunologyUniversity of North Carolina at Chapel HillChapel HillUSA
  4. 4.Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel HillChapel HillUSA

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