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Current HIV/AIDS Reports

, Volume 12, Issue 1, pp 6–15 | Cite as

Human Papillomavirus in the HIV-Infected Host: Epidemiology and Pathogenesis in the Antiretroviral Era

  • Cristina Brickman
  • Joel M. Palefsky
HIV Pathogenesis and Treatment (AL Landay, Section Editor)
Part of the following topical collections:
  1. Topical Collection on HIV Pathogenesis and Treatment

Abstract

Human papillomavirus (HPV) infection is associated with essentially all cervical cancers, 80–90 % of anal cancers, and a high proportion of oropharyngeal, vaginal, penile, and vulvar cancers. Malignancy is preceded by the development of precancerous lesions termed high-grade squamous intraepithelial lesions (HSIL). Men and women with human immunodeficiency virus (HIV) infection are at high risk of HPV-related malignancies. The incidence of anal cancer in particular has markedly risen during the antiretroviral era due to the increased longevity of patients with HIV and the absence of anal malignancy screening programs. HIV infection may facilitate initial HPV infection by disrupting epithelial cell tight junctions. Once infection is established, HIV may promote HSIL development via the up-regulation of HPV oncogene expression and impairment of the immune response needed to clear the lesion. HIV-infected women should be screened for cervical HSIL and cancer, and HIV-infected men and women should be considered for anal screening programs.

Keywords

Human papillomavirus Human immunodeficiency virus Cervical cancer Anal cancer Antiretroviral therapy Anal squamous intraepithelial lesions Cervical squamous intraepithelial lesions 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Cristina Brickman declares that she has no conflict of interest.

Joel Palefsky reports grants, travel support, and board membership from Merck & Co., Inc.; grants from Hologic; and stocks from Aura Biosciences, and he is a consultant for Qiagen.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.University of California San FranciscoSan FranciscoUSA

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