Current HIV/AIDS Reports

, Volume 11, Issue 3, pp 291–307 | Cite as

Depression and Adherence to Antiretroviral Therapy in Low-, Middle- and High-Income Countries: A Systematic Review and Meta-Analysis

  • Olalekan A. Uthman
  • Jessica F. Magidson
  • Steven A. Safren
  • Jean B. Nachega
Co-infections and Comorbidity (CM Wyatt and K Sigel, Section Editors)

Abstract

We investigated the associations between depressive symptoms and adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV). We searched the PubMed, EMBASE and Cochrane CENTRAL databases for studies that reported an association between depression and adherence to ART as a primary or secondary outcome. We used a random-effect model to pool the risk estimates from the individual studies. The odds ratio (OR) with their 95 % CIs were used as summary estimates. Of 2861 citations, 111 studies that recruited 42,366 PLHIV met our inclusion criteria. When reported, the rate of PLHIV with depressive symptoms ranged from 12.8 to 78 % and the proportion of PLHIV who achieved good adherence (≥80 %) ranged from 20 to 98 %. There were no significant differences in rate of depressive symptoms in PLHIV by country income group; however, the proportion of PLHIV who achieved good adherence was significantly higher in lower-income countries (as defined in the 2012 World Bank Country Income Groups) (pooled rate = 86 %) compared to higher-income countries (pooled rate = 67.5 %; p < .05). We found that the likelihood of achieving good ART adherence was 42 % lower among those with depressive symptoms compared to those without (pooled OR = 0.58, 95 % CI 0.55 to 0.62). The relationship between depressive symptoms and adherence to ART was consistent across the country’s income group, study design and adherence rates. We found that the magnitude of the association significantly decreases with more recent publications and increasing study sample size. The higher the prevalence of depressive symptoms of PLHIV recruited in the studies, the lower the likelihood of achieving good adherence to ART. In conclusion, the likelihood of achieving good adherence was lower among those with depressive symptoms compared to those without.

Keywords

HIV ART Depression Adherence Co-infections and comorbidity 

Notes

Acknowledgments

We thank Ms. Joyce Snyder, Pittsburgh University, Department of Epidemiology, Pittsburgh, PA, USA; and Ms. Debbie Harrison, Stellenbosch University, Department of Medicine and Center for Infectious Diseases, Cape Town, South Africa, for administrative support.

The US National Institutes for Allergy and Infectious Disease-National Institutes of Health (NIAID-NIH), AIDS Clinical Trial Group (ACTG), Stellenbosch University (SU)-Clinical Trial Unit (CTU) Award: 2UM1AI069521-08 (J. B. N.); the US NIH-Fogarty International Center (FIC)/Health Resources and Services Administration (HRSA)/US President Emergency Plan for AIDS Relief (PEPFAR) Grant Award, T84HA21652-01-00 for Medical Education Partnership Initiative (MEPI) (J. B. N.); the European Developing Countries Clinical Trial Partnership (EDCTP) Senior Fellowship Award: TA-08-40200-021 (J. B. N.); the Wellcome Trust Southern Africa Consortium for Research Excellence (SACORE): WT087537MA (J. B. N.); FAS Marie Curie International Post Doc: 2012–0064 (O. A. U.); The MGH Global Psychiatric Clinical Research Training Program: NIH T32MH093310 (J. F. M); K24MH094214 (S. A. S.).

The agencies had no role in the conduct of the study; collection, management, analysis and interpretation of the data; or preparation, review or approval of the manuscript. The conclusions and opinions expressed in this article are those of the authors and do not necessarily reflect those of the NIH, the US Department of Health and Human Services, PEPFAR, HRSA and the Wellcome Trust.

Compliance with Ethics Guidelines

Conflict of Interest

Olalekan A. Uthman, Jessica F. Magidson, Steven A. Safren, Jean B. Nachega declare that they have no conflict of interest

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

  1. 1.
    Bing EG, Burnam MA, Longshore D, Fleishman JA, Sherbourne CD, London AS, et al. Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Arch Gen Psychiatry. 2001;58(8):721–8.PubMedGoogle Scholar
  2. 2.
    Mayston R, Kinyanda E, Chishinga N, Prince M, Patel V. Mental disorder and the outcome of HIV/AIDS in low-income and middle-income countries: a systematic review. AIDS. 2012;26 Suppl 2:S117–35. doi:10.1097/QAD.0b013e32835bde0f.PubMedGoogle Scholar
  3. 3.
    Ciesla JA, Roberts JE. Meta-analysis of the relationship between HIV infection and risk for depressive disorders. Am J Psychiatry. 2001;158(5):725–30.PubMedGoogle Scholar
  4. 4.
    Gonzalez JS, Batchelder AW, Psaros C, Safren SA. Depression and HIV/AIDS treatment nonadherence: a review and meta-analysis. J Acquir Immune Defic Syndr. 2011;58(2):181–7. doi:10.1097/QAI.0b013e31822d490a.PubMedGoogle Scholar
  5. 5.
    Bangsberg DR, Hecht FM, Charlebois ED, Zolopa AR, Holodniy M, Sheiner L, et al. Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS. 2000;14(4):357–66.PubMedGoogle Scholar
  6. 6.
    Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000;133(1):21–30.PubMedGoogle Scholar
  7. 7.
    Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505. doi:10.1056/NEJMoa1105243.PubMedCentralPubMedGoogle Scholar
  8. 8.
    Bangsberg DR. Preventing HIV, antiretroviral resistance through better monitoring of treatment adherence. J Infect Dis. 2008;197 Suppl 3:S272–8. doi:10.1086/533415.PubMedGoogle Scholar
  9. 9.
    Ickovics JR, Hamburger ME, Vlahov D, Schoenbaum EE, Schuman P, Boland RJ, et al. Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study. JAMA. 2001;285(11):1466–74.PubMedGoogle Scholar
  10. 10.
    Lima VD, Geller J, Bangsberg DR, Patterson TL, Daniel M, Kerr T, et al. The effect of adherence on the association between depressive symptoms and mortality among HIV-infected individuals first initiating HAART. AIDS. 2007;21(9):1175–83. doi:10.1097/QAD.0b013e32811ebf57.PubMedGoogle Scholar
  11. 11.
    DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000;160(14):2101–7.PubMedGoogle Scholar
  12. 12.
    Nakimuli-Mpungu E, Bass JK, Alexandre P, Mills EJ, Musisi S, Ram M, et al. Depression, alcohol use and adherence to antiretroviral therapy in sub-Saharan Africa: a systematic review. AIDS Behav. 2012;16(8):2101–18. doi:10.1007/s10461-011-0087-8.PubMedGoogle Scholar
  13. 13.
    Chesney MA. Factors affecting adherence to antiretroviral therapy. Clin Infect Dis Off Publ Infect Dis Soc Am. 2000;30 Suppl 2:S171–6. doi:10.1086/313849.Google Scholar
  14. 14.
    Nachega JB, Uthman OA, Anderson J, Peltzer K, Wampold S, Cotton MF, et al. Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis. AIDS. 2012;26(16):2039–52. doi:10.1097/QAD.0b013e328359590f.PubMedGoogle Scholar
  15. 15.
    Lipsey MW, Wilson DB. Practical meta-analysis. Thousand Oaks: Sage; 2001.Google Scholar
  16. 16.
    Borenstein M, Hedges LV, Higgins JPT. Introduction to meta-analysis (Statistics in practice). Chichester: Wiley; 2009.Google Scholar
  17. 17.
    DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177–88.PubMedGoogle Scholar
  18. 18.
    Normand SL. Meta-analysis: formulating, evaluating, combining, and reporting. Stat Med. 1999;18(3):321–59.PubMedGoogle Scholar
  19. 19.
    Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–58.PubMedGoogle Scholar
  20. 20.
    Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–60.PubMedCentralPubMedGoogle Scholar
  21. 21.
    Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.PubMedCentralPubMedGoogle Scholar
  22. 22.
    Adewuya AO, Afolabi MO, Ola BA, Ogundele OA, Ajibare AO, Oladipo BF, et al. The effect of psychological distress on medication adherence in persons with HIV infection in Nigeria. Psychosomatics. 2010;51(1):68–73. doi:10.1176/appi.psy.51.1.68.PubMedGoogle Scholar
  23. 23.
    Ahdieh-Grant L, Tarwater PM, Schneider MF, Anastos K, Cohen M, Khalsa A, et al. Factors and temporal trends associated with highly active antiretroviral therapy discontinuation in the Women's Interagency HIV Study. J Acquir Immune Defic Syndr. 2005;38(4):500–3.PubMedGoogle Scholar
  24. 24.
    Amberbir A, Woldemichael K, Getachew S, Girma B, Deribe K. Predictors of adherence to antiretroviral therapy among HIV-infected persons: a prospective study in Southwest Ethiopia. BMC Pub Health. 2008;8(265). doi:10.1186/1471-2458-8-265.
  25. 25.
    Amico KR, Konkle-Parker DJ, Cornman DH, Barta WD, Ferrer R, Norton WE, et al. Reasons for ART non-adherence in the Deep South: adherence needs of a sample of HIV-positive patients in Mississippi. AIDS Care Psychol Sociol Med Asp AIDS/HIV. 2007;19(10):1210–8. doi:10.1080/09540120701426516.Google Scholar
  26. 26.
    Ammassari A, Antinori A, Aloisi MS, Trotta MP, Murri R, Bartoli L, et al. Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons. Psychosomatics. 2004;45(5):394–402.PubMedGoogle Scholar
  27. 27.
    Anastos K, Schneider MF, Gange SJ, Minkoff H, Greenblatt RM, Feldman J, et al. The association of race, sociodemographic, and behavioral characteristics with response to highly active antiretroviral therapy in women. J Acquir Immune Defic Syndr. 2005;39(5):537–44.PubMedGoogle Scholar
  28. 28.
    Applebaum AJ, Reilly LC, Gonzalez JS, Richardson MA, Leveroni CL, Safren SA. The impact of neuropsychological functioning on adherence to HAART in HIV-infected substance abuse patients. AIDS Patient Care STDs. 2009;23(6):455–62. doi:10.1089/apc.2008.0181.PubMedCentralPubMedGoogle Scholar
  29. 29.
    Arnsten JH, Li X, Mizuno Y, Knowlton AR, Gourevitch MN, Handley K et al. Factors associated with antiretroviral therapy adherence and medication errors among HIV-infected injection drug users. J Acquir Immune Defic Syndr. 2007;46(SUPPL. 2):S64-S71. doi:10.1097/QAI.0b013e31815767d6.
  30. 30.
    Avants SK, Margolin A, Warburton LA, Hawkins KA, Shi J. Predictors of nonadherence to HIV-related medication regimens during methadone stabilization. Am J Addict. 2001;10(1):69–78. doi:10.1080/105504901750160501.PubMedGoogle Scholar
  31. 31.
    Barfod TS, Gerstoft J, Rodkjaer L, Pedersen C, Nielsen H, Moller A, et al. Patients' answers to simple questions about treatment satisfaction and adherence and depression are associated with failure of HAART: a cross-sectional survey.[Erratum appears in AIDS Patient Care STDS. 2005 Aug;19(8):544]. AIDS Patient Care STDS. 2005;19(5):317–25.PubMedGoogle Scholar
  32. 32.
    Berg KM, Cooperman NA, Newville H, Arnsten JH. Self-efficacy and depression as mediators of the relationship between pain and antiretroviral adherence. AIDS Care Psychol Sociol Med Asp AIDS/HIV. 2009;21(2):244–8. doi:10.1080/09540120802001697.Google Scholar
  33. 33.
    Berg KM, Demas PA, Howard AA, Schoenbaum EE, Gourevitch MN, Arnsten JH. Gender differences in factors associated with adherence to antiretroviral therapy. J Gen Intern Med. 2004;19(11):1111–7.PubMedCentralPubMedGoogle Scholar
  34. 34.
    Berger-Greenstein JA, Cuevas CA, Brady SM, Trezza G, Richardson MA, Keane TM. Major depression in patients with HIV/AIDS and substance abuse. AIDS Patient Care STDs. 2007;21(12):942–55. doi:10.1089/apc.2006.0153.PubMedGoogle Scholar
  35. 35.
    Boarts JM, Sledjeski EM, Bogart LM, Delahanty DL. The differential impact of PTSD and depression on HIV disease markers and adherence to HAART in people living with HIV. AIDS Behav. 2006;10(3):253–61. doi:10.1007/s10461-006-9069-7.PubMedGoogle Scholar
  36. 36.
    Bottonari KA, Roberts JE, Ciesla JA, Hewitt RG. Life stress and adherence to antiretroviral therapy among HIV-positive individuals: a preliminary investigation. AIDS Patient Care STDs. 2005;19(11):719–27. doi:10.1089/apc.2005.19.719.PubMedGoogle Scholar
  37. 37.
    Byakika-Tusiime J, Crane J, Oyugi JH, Ragland K, Kawuma A, Musoke P, et al. Longitudinal antiretroviral adherence in HIV+ Ugandan parents and their children initiating HAART in the MTCT-Plus family treatment model: role of depression in declining adherence over time. AIDS Behav. 2009;13 Suppl 1:82–91. doi:10.1007/s10461-009-9546-x.PubMedGoogle Scholar
  38. 38.
    Cardarelli R, Weis S, Adams E, Radaford D, Vecino I, Munguia G, et al. General health status and adherence to antiretroviral therapy. J Int Assoc Phys AIDS Care (Chicago, Ill). 2008;7(3):123–9. doi:10.1177/1545109708318526.Google Scholar
  39. 39.
    Carrieri MP, Chesney MA, Spire B, Loundou A, Sobel A, Lepeu G, et al. Failure to maintain adherence to HAART in a cohort of French HIV-positive injecting drug users. Int J Behav Med. 2003;10(1):1–14.PubMedGoogle Scholar
  40. 40.
    Catz SL, Heckman TG, Kochman A, DiMarco M. Rates and correlates of HIV treatment adherence among late middle-aged and older adults living with HIV disease. Psychol Health Med. 2001;6(1):47–58.Google Scholar
  41. 41.
    Catz SL, Kelly JA, Bogart LM, Benotsch EG, McAuliffe TL. Patterns, correlates, and barriers to medication adherence among persons prescribed new treatments for HIV disease. Health Psychol. 2000;19(2):124–33. doi:10.1037//0278-6133.19.2.124.PubMedGoogle Scholar
  42. 42.
    Cha E, Erlen JA, Kim KH, Sereika SM, Caruthers D. Mediating roles of medication-taking self-efficacy and depressive symptoms on self-reported medication adherence in persons with HIV: a questionnaire survey. Int J Nurs Stud. 2008;45(8):1175–84.PubMedCentralPubMedGoogle Scholar
  43. 43.
    Cook JA, Grey D, Burke J, Cohen MH, Gurtman AC, Richardson JL, et al. Depressive symptoms and AIDS-related mortality among a multisite cohort of HIV-positive women. Am J Public Health. 2004;94(7):1133–40.PubMedCentralPubMedGoogle Scholar
  44. 44.
    Cruess DG, Minor S, Antoni MH, Millon T. Utility of the Millon Behavioral Medicine Diagnostic (MBMD) to predict adherence to Highly Active Antiretroviral Therapy (HAART) medication regimens among HIV-positive men and women. J Pers Assess. 2007;89(3):277–90.PubMedGoogle Scholar
  45. 45.
    De AK, Dalui A. Assessment of factors influencing adherence to anti-retroviral therapy for human immunodeficiency virus positive mothers and their infected children. Indian J Med Sci. 2012;66(11):247–59. doi:10.4103/0019-5359.115733.PubMedGoogle Scholar
  46. 46.
    Delgado J, Heath KV, Yip B, Marion S, Alfonso V, Montaner JS, et al. Highly active antiretroviral therapy: physician experience and enhanced adherence to prescription refill. Antivir Ther. 2003;8(5):471–8.PubMedGoogle Scholar
  47. 47.
    Demas P, Schoenbaum EE, Hirky AE, Wills TA, Doll LS, Hartel DM, et al. The relationship of HIV treatment acceptance and adherence to psyschosocial factors among injecting drug users. AIDS Behav. 1998;2(4):283–91.Google Scholar
  48. 48.
    DiIorio C, McCarty F, DePadilla L, Resnicow K, Holstad MM, Yeager K, et al. Adherence to antiretroviral medication regimens: a test of a psychosocial model. AIDS Behav. 2009;13(1):10–22. doi:10.1007/s10461-007-9318-4.PubMedCentralPubMedGoogle Scholar
  49. 49.
    Do HM, Dunne MP, Kato M, Pham CV, Nguyen KV. Factors associated with suboptimal adherence to antiretroviral therapy in Viet Nam: a cross-sectional study using audio computer-assisted self-interview (ACASI). BMC Infectious Diseases. 2013;13(1). doi:10.1186/1471-2334-13-154.
  50. 50.
    Do NT, Phiri K, Bussmann H, Gaolathe T, Marlink RG, Wester CW. Psychosocial factors affecting medication adherence among HIV-1 infected adults receiving combination antiretroviral therapy (cART) in Botswana. AIDS Res Hum Retrovir. 2010;26(6):685–91. doi:10.1089/aid.2009.0222.PubMedCentralPubMedGoogle Scholar
  51. 51.
    Duran S, Saves M, Spire B, Cailleton V, Sobel A, Carrieri P, et al. Failure to maintain long-term adherence to highly active antiretroviral therapy: the role of lipodystrophy. AIDS. 2001;15(18):2441–4.PubMedGoogle Scholar
  52. 52.
    Etienne M, Hossain M, Redfield R, Stafford K, Amoroso A. Indicators of adherence to antiretroviral therapy treatment among HIV/AIDS patients in 5 African countries. J Int Assoc Phys AIDS Care (Chic). 2010;9(2):98–103. doi:10.1177/1545109710361383.Google Scholar
  53. 53.
    Farley J, Miller E, Zamani A, Tepper V, Morris C, Oyegunle M, et al. Screening for hazardous alcohol use and depressive symptomatology among HIV-infected patients in Nigeria: prevalence, predictors, and association with adherence. J Int Assoc Phys AIDS Care (Chic). 2010;9(4):218–26. doi:10.1177/1545109710371133.Google Scholar
  54. 54.
    Gibbie T, Hay M, Hutchison CW, Mijch A. Depression, social support and adherence to highly active antiretroviral therapy in people living with HIV/AIDS. Sex Health. 2007;4(4):227–32. doi:10.1071/SH06062.PubMedGoogle Scholar
  55. 55.
    Gifford AL, Bormann JE, Shively MJ, Wright BC, Richman DD, Bozzette SA. Predictors of self-reported adherence and plasma HIV concentrations in patients on multidrug antiretroviral regimens. J Acquir Immune Defic Syndr. 2000;23(5):386–95.PubMedGoogle Scholar
  56. 56.
    Gonzalez JS, Penedo FJ, Antoni MH, Duran RE, McPherson-Baker S, Ironson G, et al. Social support, positive states of mind, and HIV treatment adherence in men and women living with HIV/AIDS. Health Psychol. 2004;23(4):413–8.PubMedGoogle Scholar
  57. 57.
    Gordillo V, del Amo J, Soriano V, Gonzalez-Lahoz J. Sociodemographic and psychological variables influencing adherence to antiretroviral therapy. AIDS. 1999;13(13):1763–9.PubMedGoogle Scholar
  58. 58.
    Herrmann S, McKinnon E, John M, Hyland N, Martinez OP, Cain A, et al. Evidence-based, multifactorial approach to addressing non-adherence to antiretroviral therapy and improving standards of care. Intern Med J. 2008;38(1):8–15. doi:10.1111/j.1445-5994.2007.01477.x.PubMedGoogle Scholar
  59. 59.
    Hilerio CM, Martinez J, Zorrilla CD, Torres R. Posttraumatic stress disorder symptoms and adherence among women living with HIV. Ethn Dis. 2005;15(4 SUPPL. 5).Google Scholar
  60. 60.
    Holmes WC, Bilker WB, Wang H, Chapman J, Gross R. HIV/AIDS-specific quality of life and adherence to antiretroviral therapy over time. J Acquir Immune Defic Syndr. 2007;46(3):323–7. doi:10.1097/QAI.0b013e31815724fe.PubMedGoogle Scholar
  61. 61.
    Horberg MA, Silverberg MJ, Hurley LB, Towner WJ, Klein DB, Bersoff-Matcha S, et al. Effects of depression and selective serotonin reuptake inhibitor use on adherence to highly active antiretroviral therapy and on clinical outcomes in HIV-infected patients. J Acquir Immune Defic Syndr. 2008;47(3):384–90. doi:10.1097/QAI.0b013e318160d53e.PubMedGoogle Scholar
  62. 62.
    Horne R, Cooper V, Gellaitry G, Date HL, Fisher M. Patients' perceptions of highly active antiretroviral therapy in relation to treatment uptake and adherence: the utility of the necessity-concerns framework. J Acquir Immune Defic Syndr. 2007;45(3):334–41. doi:10.1097/QAI.0b013e31806910e3.PubMedGoogle Scholar
  63. 63.
    Ingersoll K. The impact of psychiatric symptoms, drug use, and medication regimen on non-adherence to HIV treatment. AIDS Care Psychol Sociol Med Asp AIDS/HIV. 2004;16(2):199–211. doi:10.1080/09540120410001641048.Google Scholar
  64. 64.
    Ironson G, O'Cleirigh C, Fletcher MA, Laurenceau JP, Balbin E, Klimas N, et al. Psychosocial factors predict CD4 and viral load change in men and women with human immunodeficiency virus in the era of highly active antiretroviral treatment. Psychosom Med. 2005;67(6):1013–21.PubMedCentralPubMedGoogle Scholar
  65. 65.
    Johnson MO, Catz SL, Remien RH, Rotheram-Borus MJ, Morin SF, Charlebois E, et al. Theory-guided, empirically supported avenues for intervention on HIV medication nonadherence: findings from the Healthy Living Project. AIDS Patient Care STDS. 2003;17(12):645–56. doi:10.1089/108729103771928708.PubMedGoogle Scholar
  66. 66.
    Johnson MO, Dilworth SE, Neilands TB, Chesney MA, Rotheram-Borus MJ, Remien RH, et al. Predictors of attrition among high risk HIV-infected participants enrolled in a multi-site prevention trial. AIDS Behav. 2008;12(6):974–7. doi:10.1007/s10461-007-9356-y.PubMedCentralPubMedGoogle Scholar
  67. 67.
    Kacanek D, Jacobson DL, Spiegelman D, Wanke C, Isaac R, Wilson IB. Incident depression symptoms are associated with poorer HAART adherence: a longitudinal analysis from the nutrition for healthy living study. J Acquir Immune Defic Syndr. 2010;53(2):266–72. doi:10.1097/QAI.0b013e3181b720e7.PubMedCentralPubMedGoogle Scholar
  68. 68.
    Kalichman SC, Rompa D. HIV treatment adherence and unprotected sex practices in people receiving antiretroviral therapy. Sex Transm Infect. 2003;79(1):59–61.PubMedCentralPubMedGoogle Scholar
  69. 69.
    Kalichman SC, Rompa D, DiFonzo K, Simpson D, Austin J, Luke W, et al. HIV treatment adherence in women living with HIV/AIDS: research based on the Information-Motivation-Behavioral Skills model of health behavior. J Assoc Nurses AIDS Care. 2001;12(4):58–67.PubMedGoogle Scholar
  70. 70.
    Kapetanovic S, Christensen S, Karim R, Lin F, Mack WJ, Operskalski E, et al. Correlates of perinatal depression in HIV-infected women. AIDS Patient Care STDs. 2009;23(2):101–8. doi:10.1089/apc.2008.0125.PubMedCentralPubMedGoogle Scholar
  71. 71.
    Kekwaletswe C, Morojele N, Nkosi S. Depression, alcohol use and adherence to antiretroviral therapy (ART). 6th International AIDS Society Conference on HIV Pathogenesis and Treatment. Rome; 2011.Google Scholar
  72. 72.
    Kennedy S, Goggin K, Nollen N. Adherence to HIV medications: utility of the theory of self-determination. Cogn Ther Res. 2004;28(5):611–28. doi:10.1023/B:COTR.0000045568.95219.e2.Google Scholar
  73. 73.
    Kim TW, Palepu A, Cheng DM, Libman H, Saitz R, Samet JH. Factors associated with discontinuation of antiretroviral therapy in HIV-infected patients with alcohol problems. AIDS Care. 2007;19(8):1039–47.PubMedCentralPubMedGoogle Scholar
  74. 74.
    King RM, Vidrine DJ, Danysh HE, Fletcher FE, McCurdy S, Arduino RC, et al. Factors associated with nonadherence to antiretroviral therapy in HIV-positive smokers. AIDS Patient Care STDS. 2012;26(8):479–85. doi:10.1089/apc.2012.0070.PubMedGoogle Scholar
  75. 75.
    Kleeberger CA, Buechner J, Palella F, Detels R, Riddler S, Godfrey R, et al. Changes in adherence to highly active antiretroviral therapy medications in the Multicenter AIDS Cohort Study. AIDS. 2004;18(4):683–8. doi:10.1097/00002030-200403050-00013.PubMedGoogle Scholar
  76. 76.
    Leserman J, Ironson G, O'Cleirigh C, Fordiani JM, Balbin E. Stressful life events and adherence in HIV. AIDS Patient Care STDs. 2008;22(5):403–11. doi:10.1089/apc.2007.0175.PubMedCentralPubMedGoogle Scholar
  77. 77.
    Li X, Margolick JB, Conover CS, Badri S, Riddler SA, Witt MD, et al. Interruption and discontinuation of highly active antiretroviral therapy in the multicenter AIDS cohort study. J Acquir Immune Defic Syndr. 2005;38(3):320–8.PubMedGoogle Scholar
  78. 78.
    Littlewood RA, Vanable PA, Carey MP, Blair DC. The association of benefit finding to psychosocial and health behavior adaptation among HIV + men and women. J Behav Med. 2008;31(2):145–55. doi:10.1007/s10865-007-9142-3.PubMedCentralPubMedGoogle Scholar
  79. 79.
    Liu H, Longshore D, Williams JK, Rivkin I, Loeb T, Warda US, et al. Substance abuse and medication adherence among HIV-positive women with histories of child sexual abuse. AIDS Behav. 2006;10(3):279–86. doi:10.1007/s10461-005-9041-y.PubMedGoogle Scholar
  80. 80.
    Markos E, Worku A, Davey G. Adherence to ART in PLWHA at Yirgalem hospital, South Ethiopia. Ethiop J Health Dev. 2008;22:174–9.Google Scholar
  81. 81.
    Meade CS, Hansen NB, Kochman A, Sikkema KJ. Utilization of medical treatments and adherence to antiretroviral therapy among HIV-positive adults with histories of childhood sexual abuse. AIDS Patient Care STDS. 2009;23(4):259–66. doi:10.1089/apc.2008.0210.PubMedCentralPubMedGoogle Scholar
  82. 82.
    Mohammed H, Kieltyka L, Richardson-Alston G, Magnus M, Fawal H, Vermund SH, et al. Adherence to HAART among HIV-infected persons in rural Louisiana. AIDS Patient Care STDs. 2004;18(5):289–96. doi:10.1089/108729104323076025.PubMedGoogle Scholar
  83. 83.
    Molassiotis A, Nahas-Lopez V, Chung WYR, Lam SWC, Li CKP, Lau TFJ. Factors associated with adherence to antiretroviral medication in HIV infected patients. Int J STD AIDS. 2002;13(5):301–10. doi:10.1258/0956462021925117.PubMedGoogle Scholar
  84. 84.
    Moss AR, Hahn JA, Perry S, Charlebois ED, Guzman D, Clark RA et al. Adherence to highly active antiretroviral therapy in the homeless population in San Francisco: a prospective study. Clin Infect Dis. 39(8):1190–8. doi:10.1086/424008.
  85. 85.
    Mugavero M, Ostermann J, Whetten K, Leserman J, Swartz M, Stangl D, et al. Barriers to antiretroviral adherence: the importance of depression, abuse, and other traumatic events. AIDS Patient Care STDs. 2006;20(6):418–28. doi:10.1089/apc.2006.20.418.PubMedGoogle Scholar
  86. 86.
    Murphy DA, Marelich WD, Huffman D, Steers WN. Predictors of antiretroviral adherence. AIDS Care Psychol Sociol Med Asp AIDS/HIV. 2004;16(4):471–84. doi:10.1080/09540120410001683402.Google Scholar
  87. 87.
    Murphy DA, Wilson CM, Durako SJ, Muenz LR, Belzer M, Adolescent Medicine HIVARN. Antiretroviral medication adherence among the REACH HIV-infected adolescent cohort in the USA. AIDS Care. 2001;13(1):27–40.PubMedGoogle Scholar
  88. 88.
    Nachega J, Morroni C, Ram M, Efron E, Chaisson RE, Maartens G. Impact of concurrent TB treatment on ART adherence and liver toxicity in South African adults. [Poster#883]. 18th Conference on retroviruses and opportunistic infection; Boston; 2011.Google Scholar
  89. 89.
    Nakimuli-Mpungu E, Mojtabai R, Alexandre PK, Musisi S, Katabira E, Nachega JB, et al. Lifetime depressive disorders and adherence to anti-retroviral therapy in HIV-infected Ugandan adults: A case–control study. J Affect Disord. 2013;145(2):221–6. doi:10.1016/j.jad.2012.08.002.PubMedGoogle Scholar
  90. 90.
    Nakimuli–Mpungu E, Munyaneza G. Depression alcohol abuse and disclosure of HIV serostatus among rural HIV-positive individuals in western Uganda. Neurobehav HIV Med. 2011;3:19–25.Google Scholar
  91. 91.
    Nakimuli-Mpungu E, Mutamba B, Othengo M, Musisi S. Psychological distress and adherence to highly active anti-retroviral therapy (HAART) in Uganda: a pilot study. Afr Health Sci. 2009;9 Suppl 1:S2–7.PubMedCentralPubMedGoogle Scholar
  92. 92.
    Nannis ED, Temoshok LR, Smith M, Jenkins RA. Perceptions of AZT: implications for adherence to medical regimens1. J Appl Biobehav Res. 1993;1(1):39–54. doi:10.1111/j.1751-9861.1993.tb00026.x.Google Scholar
  93. 93.
    Nel A, Kagee A. The relationship between depression, anxiety and medication adherence among patients receiving antiretroviral treatment in South Africa. AIDS Care Psychol Sociol Med Asp AIDS/HIV. 2013;25(8):948–55. doi:10.1080/09540121.2012.748867.Google Scholar
  94. 94.
    Nilsson Schonnesson L, Williams ML, Ross MW, Bratt G, Keel B. Factors associated with suboptimal antiretroviral therapy adherence to dose, schedule, and dietary instructions. AIDS Behav. 2007;11(2):175–83. doi:10.1007/s10461-006-9160-0.PubMedGoogle Scholar
  95. 95.
    O'Cleirigh C, Ironson G, Smits JAJ. Does distress tolerance moderate the impact of major life events on psychosocial variables and behaviors important in the management of HIV? Behav Ther. 2007;38(3):314–23. doi:10.1016/j.beth.2006.11.001.PubMedCentralPubMedGoogle Scholar
  96. 96.
    O'Cleirigh C, Safren SA. Domains of life satisfaction among patients living with HIV: A factor analytic study of the quality of life inventory. AIDS Behav. 2006. doi:10.1007/s10461-005-9027-9.PubMedGoogle Scholar
  97. 97.
    Palepu A, Horton NJ, Tibbetts N, Meli S, Samet JH. Uptake and adherence to highly active antiretroviral therapy among HIV-infected people with alcohol and other substance use problems: the impact of substance abuse treatment. Addiction (Abingdon, England). 2004. doi:10.1111/j.1360-0443.2003.00670.x.
  98. 98.
    Palmer NB, Salcedo J, Miller AL, Winiarski M, Arno P. Psychiatric and social barriers to HIV medication adherence in a triply diagnosed methadone population. AIDS Patient Care STDS. 2003;17(12):635–44. doi:10.1089/108729103771928690.PubMedGoogle Scholar
  99. 99.
    Peltzer K, Friend-du Preez N, Ramlagan S, Anderson J. Antiretroviral treatment adherence among HIV patients in KwaZulu-Natal. S Afr BMC Public Health. 2010;10:111. doi:10.1186/1471-2458-10-111.Google Scholar
  100. 100.
    Phillips KD, Moneyham L, Murdaugh C, Boyd MR, Tavakoli A, Jackson K, et al. Sleep disturbance and depression as barriers to adherence. Clin Nurs Res. 2005;14(3):273–93. doi:10.1177/1054773805275122.PubMedGoogle Scholar
  101. 101.
    Pratt RJ, Robinson N, Loveday HP, Pellowe CM, Franks PJ, Hankins M, et al. Adherence to antiretroviral therapy: appropriate use of self-reporting in clinical practice. HIV Clin Trials. 2001;2(2):146–59.PubMedGoogle Scholar
  102. 102.
    Ramadhani HO, Thielman NM, Landman KZ, Ndosi EM, Gao F, Kirchherr JL, et al. Predictors of incomplete adherence, virologic failure, and antiviral drug resistance among HIV-infected adults receiving antiretroviral therapy in Tanzania. Clin Infect Dis Off Publ Infect Dis Soc Am. 2007;45(11):1492–8. doi:10.1086/522991.Google Scholar
  103. 103.
    Roux P, Carrieri MP, Villes V, Dellamonica P, Poizot-Martin I, Ravaux I, et al. The impact of methadone or buprenorphine treatment and ongoing injection on highly active antiretroviral therapy (HAART) adherence: evidence from the MANIF2000 cohort study. Addiction. 2008;103(11):1828–36. doi:10.1111/j.1360-0443.2008.02323.x.PubMedGoogle Scholar
  104. 104.
    Royal SW, Kidder DP, Patrabansh S, Wolitski RJ, Holtgrave DR, Aidala A, et al. Factors associated with adherence to highly active antiretroviral therapy in homeless or unstably housed adults living with HIV. AIDS Care Psychol Sociol Med Asp AIDS/HIV. 2009;21(4):448–55. doi:10.1080/09540120802270250.Google Scholar
  105. 105.
    Safren SA, Otto MW, Worth JL, Salomon E, Johnson W, Mayer K, et al. Two strategies to increase adherence to HIV antiretroviral medication: life-steps and medication monitoring. Behav Res Ther. 2001;39(10):1151–62.PubMedGoogle Scholar
  106. 106.
    Samet JH, Horton NJ, Meli S, Freedberg KA, Palepu A. Alcohol consumption and antiretroviral adherence among HIV-infected persons with alcohol problems. Alcohol Clin Exp Res. 2004;28(4):572–7. doi:10.1097/01.ALC.0000122103.74491.78.PubMedGoogle Scholar
  107. 107.
    Sarna A, Pujari S, Sengar AK, Garg R, Gupta I, Dam J. Adherence to antiretroviral therapy & its determinants amongst HIV patients in India. Indian J Med Res. 2008;127(1):28–36.PubMedGoogle Scholar
  108. 108.
    Shin S, Munoz M, Espiritu B, Zeladita J, Sanchez E, Callacna M, et al. Psychosocial impact of poverty on antiretroviral nonadherence among HIV-TB coinfected patients in Lima, Peru. J Int Assoc Phys AIDS Care (Chicago, Ill). 2008;7(2):74–81. doi:10.1177/1545109708315326.Google Scholar
  109. 109.
    Shuter J, Bernstein SL. Cigarette smoking is an independent predictor of nonadherence in HIV-infected individuals receiving highly active antiretroviral therapy. Nicotine Tob Res. 2008;10(4):731–6. doi:10.1080/14622200801908190.PubMedGoogle Scholar
  110. 110.
    Simoni JM, Frick PA, Lockhart D, Liebovitz D. Mediators of social support and antiretroviral adherence among an indigent population in New York City. AIDS Patient Care STDs. 2002;16(9):431–9. doi:10.1089/108729102760330272.PubMedGoogle Scholar
  111. 111.
    Simoni JM, Huh D, Wilson IB, Shen J, Goggin K, Reynolds NR, et al. Racial/ethnic disparities in ART adherence in the United States: findings from the MACH14 study. J Acquir Immune Defic Syndr. 2012;60(5):466–72. doi:10.1097/QAI.0b013e31825db0bd.PubMedCentralPubMedGoogle Scholar
  112. 112.
    Singh N, Squier C, Sivek C, Nguyen MH, Wagener M, Yu VL. Determinants of nontraditional therapy use in patients with HIV infection: a prospective study. Arch Intern Med. 1996;156(2):197–201. doi:10.1001/archinte.156.2.197.PubMedGoogle Scholar
  113. 113.
    Sledjeski EM, Delahanty DL, Bogart LM. Incidence and impact of posttraumatic stress disorder and comorbid depression on adherence to HAART and CD4+ counts in people living with HIV. AIDS Patient Care STDs. 2005;19(11):728–36. doi:10.1089/apc.2005.19.728.PubMedGoogle Scholar
  114. 114.
    Spire B, Duran S, Souville M, Leport C, Raffi F, Moatti JP, et al. Adherence to highly active antiretroviral therapies (HAART) in HIV-infected patients: from a predictive to a dynamic approach. Soc Sci Med. 2002;54(10):1481–96.PubMedGoogle Scholar
  115. 115.
    Stone VE, Jordan J, Tolson J, Miller R, Pilon T. Perspectives on adherence and simplicity for HIV-infected patients on antiretroviral therapy: self-report of the relative importance of multiple attributes of highly active antiretroviral therapy (HAART) regimens in predicting adherence. J Acquir Immune Defic Syndr. 2004;36(3):808–16.PubMedGoogle Scholar
  116. 116.
    Tadios Y, Davey G. Antiretroviral treatment adherence and its correlates in Addis Ababa, Ethiopia. Ethiopian Medical Journal. 2006;44(3):237–44.PubMedGoogle Scholar
  117. 117.
    Thrasher AD, Earp JA, Golin CE, Zimmer CR. Discrimination, distrust, and racial/ethnic disparities in antiretroviral therapy adherence among a national sample of HIV-infected patients. J Acquir Immune Defic Syndr. 2008;49(1):84–93. doi:10.1097/QAI.0b013e3181845589.PubMedGoogle Scholar
  118. 118.
    Tucker JS, Burnam MA, Sherbourne CD, Kung FY, Gifford AL. Substance use and mental health correlates of nonadherence to antiretroviral medications in a sample of patients with human immunodeficiency virus infection. Am J Med. 2003;114(7):573–80. doi:10.1016/S0002-9343%2803%2900093-7.PubMedGoogle Scholar
  119. 119.
    Turner BJ, Laine C, Cosler L, Hauck WW. Relationship of gender, depression, and health care delivery with antiretroviral adherence in HIV-infected drug users. J Gen Intern Med. 2003;18(4):248–57. doi:10.1046/j.1525-1497.2003.20122.x.PubMedCentralPubMedGoogle Scholar
  120. 120.
    Van Servellen G, Chang B, Garcia L, Lombardi E. Individual and system level factors associated with treatment nonadherence in human immunodeficiency virus-infected men and women. AIDS Patient Care STDs. 2002;16(6):269–81. doi:10.1089/10872910260066705.PubMedGoogle Scholar
  121. 121.
    Villes V, Spire B, Lewden C, Perronne C, Besnier JM, Garre M, et al. The effect of depressive symptoms at ART initiation on HIV clinical progression and mortality: implications in clinical practice. Antivir Ther. 2007;12(7):1067–74.PubMedGoogle Scholar
  122. 122.
    Vranceanu AM, Safren SA, Lu M, Coady WM, Skolnik PR, Rogers WH, et al. The relationship of post-traumatic stress disorder and depression to antiretroviral medication adherence in persons with HIV. AIDS Patient Care STDs. 2008;22(4):313–21. doi:10.1089/apc.2007.0069.PubMedGoogle Scholar
  123. 123.
    Wagner GJ, Kanouse DE, Koegel P, Sullivan G. Adherence to HIV antiretrovirals among persons with serious mental illness. AIDS Patient Care STDS. 2003;17(4):179–86. doi:10.1089/108729103321619782.PubMedGoogle Scholar
  124. 124.
    Wagner JH, Justice AC, Chesney M, Sinclair G, Weissman S, Rodriguez-Barradas M. Patient- and provider-reported adherence: toward a clinically useful approach to measuring antiretroviral adherence. J Clin Epidemiol. 2001;1:S91–8.Google Scholar
  125. 125.
    Waldrop-Valverde D, Ownby RL, Wilkie FL, Mack A, Kumar M, Metsch L. Neurocognitive aspects of medication adherence in HIV-positive injecting drug users. AIDS Behav. 2006;10(3):287–97.PubMedGoogle Scholar
  126. 126.
    Webb MS, Vanable PA, Carey MP, Blair DC. Medication adherence in HIV-infected smokers: The mediating role of depressive symptoms. AIDS Educ Prev. 2009;21(SUPPL. 3):94–105. doi:10.1521/aeap.2009.21.3_supp.94.
  127. 127.
    Wilson IB, Tchetgen E, Spiegelman D. Patterns of adherence with antiretroviral medications: an examination of between-medication differences. J Acquir Immune Defic Syndr. 2001;28(3):259–63.PubMedGoogle Scholar
  128. 128.
    Wilson KJ, Doxanakis A, Fairley CK. Predictors for non-adherence to antiretroviral therapy. Sex Health. 2004;1(4):251–7.PubMedGoogle Scholar
  129. 129.
    Woods SP, Dawson MS, Weber E, Gibson S, Grant I, Atkinson JH, et al. Timing is everything: antiretroviral nonadherence is associated with impairment in time-based prospective memory. J Int Neuropsychol Soc. 2009;15(1):42–52. doi:10.1017/S1355617708090012.PubMedCentralPubMedGoogle Scholar
  130. 130.
    Yun LWH, Maravi M, Kobayashi JS, Barton PL, Davidson AJ. Antidepressant treatment improves adherence to antiretroviral therapy among depressed HIV-infected patients. J Acquir Immune Defic Syndr. 2005;38(4):432–8. doi:10.1097/01.qai.0000147524.19122.fd.PubMedGoogle Scholar
  131. 131.
    Tsai AC. Reliability and validity of depression assessment among persons with HIV in sub-Saharan Africa: systematic review and meta-analysis. J Acquir Immune Defic Syndr. 2014. doi:10.1097/QAI.0000000000000210.Google Scholar
  132. 132.
    Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, Singh S, et al. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA. 2006;296(6):679–90. doi:10.1001/jama.296.6.679.PubMedGoogle Scholar
  133. 133.
    Pyne JM, Fortney JC, Curran GM, Tripathi S, Atkinson JH, Kilbourne AM, et al. Effectiveness of collaborative care for depression in human immunodeficiency virus clinics. Arch Intern Med. 2011;171(1):23–31. doi:10.1001/archinternmed.2010.395.PubMedGoogle Scholar
  134. 134.
    Pence BW, Gaynes BN, Williams Q, Modi R, Adams J, Quinlivan EB, et al. Assessing the effect of Measurement-Based Care depression treatment on HIV medication adherence and health outcomes: rationale and design of the SLAM DUNC Study. Contemp Clin Trials. 2012;33(4):828–38. doi:10.1016/j.cct.2012.04.002.PubMedCentralPubMedGoogle Scholar
  135. 135.
    Kaaya S, Eustache E, Lapidos-Salaiz I, Musisi S, Psaros C, Wissow L. Grand challenges: improving HIV treatment outcomes by integrating interventions for co-morbid mental illness. PLoS Med. 2013;10(5):e1001447. doi:10.1371/journal.pmed.1001447.PubMedCentralPubMedGoogle Scholar
  136. 136.
    Nachega JB, Parienti JJ, Uthman OA, Gross R, Dowdy DW, Sax PE, et al. Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: a meta-analysis of randomized controlled trials. Clin Infect Dis Off Publ Infect Dis Soc Am. 2014;58(9):1297–307. doi:10.1093/cid/ciu046.Google Scholar
  137. 137.
    Safren SA, O'Cleirigh C, Tan JY, Raminani SR, Reilly LC, Otto MW, et al. A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected individuals. Health Psychol Off J Div Health Psychol Am Psychol Assoc. 2009;28(1):1–10. doi:10.1037/a0012715.Google Scholar
  138. 138.
    Safren SA, O'Cleirigh CM, Bullis JR, Otto MW, Stein MD, Pollack MH. Cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected injection drug users: a randomized controlled trial. J Consult Clin Psychol. 2012;80(3):404–15. doi:10.1037/a0028208.PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Olalekan A. Uthman
    • 1
    • 2
  • Jessica F. Magidson
    • 3
    • 4
  • Steven A. Safren
    • 3
  • Jean B. Nachega
    • 5
    • 6
    • 7
    • 8
  1. 1.Warwick-Centre for Applied Health Research and Delivery (WCARHD), Division of Health Sciences, Warwick Medical SchoolThe University of WarwickCoventryUK
  2. 2.Liverpool School of Tropical MedicineInternational Health GroupLiverpoolUK
  3. 3.Behavioral Medicine Service, Department of PsychiatryMassachusetts General Hospital/Harvard Medical SchoolBostonUSA
  4. 4.The Chester M. Pierce, MD Division of Global Psychiatry, Department of PsychiatryMassachusetts General Hospital/Harvard Medical SchoolBostonUSA
  5. 5.Department of Epidemiology, Infectious Diseases Epidemiology Research ProgramPittsburgh University Graduate School of Public HealthPittsburghUSA
  6. 6.Departments of Epidemiology and International HealthJohns Hopkins Bloomberg School of Public HealthBaltimoreUSA
  7. 7.Department of Medicine and Centre for Infectious Diseases, Faculty of Medicine and Health SciencesStellenbosch UniversityCape TownSouth Africa
  8. 8.Medicine and Epidemiology, Department of Epidemiology, Infectious Diseases Epidemiology Research ProgramPittsburgh University, Graduate School of Public HealthPittsburghUSA

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