Current HIV/AIDS Reports

, Volume 9, Issue 1, pp 73–80 | Cite as

The Cell Biology of TRIM5α

  • Zana Lukic
  • Edward M. CampbellEmail author
The Science of HIV (AL Landay, Section Editor)


The tripartite motif (TRIM)–containing proteins are involved in many cellular functions such as cell signaling, apoptosis, cell differentiation, and immune modulation. TRIM5 proteins, including TRIM5α and TRIM-Cyp, are known to possess antiretroviral activity against many different retroviruses. Besides being retroviral restriction factors, TRIM5 proteins participate in other cellular functions that have recently emerged in the study of TRIM5α. In this review, we discuss properties of TRIM5α such as cytoplasmic body formation, protein turnover, and trafficking. Also, we discuss recent insights into innate immune modulation mediated by TRIM5α, highlighting the various functions TRIM5α has in cellular processes.


rhTRIM5alpha Cytoplasmic bodies HIV-1 Restriction factor Signaling 2 



No potential conflicts of interest relevant to this article were reported.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Microbiology and Immunology, Stritch School of MedicineLoyola University ChicagoMaywoodUSA

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