Current HIV/AIDS Reports

, Volume 8, Issue 1, pp 62–72 | Cite as

Combination HIV Prevention: Significance, Challenges, and Opportunities

  • Ann E. KurthEmail author
  • Connie Celum
  • Jared M. Baeten
  • Sten H. Vermund
  • Judith N. Wasserheit


No single HIV prevention strategy will be sufficient to control the HIV pandemic. However, a growing number of interventions have shown promise in partially protecting against HIV transmission and acquisition, including knowledge of HIV serostatus, behavioral risk reduction, condoms, male circumcision, needle exchange, treatment of curable sexually transmitted infections, and use of systemic and topical antiretroviral medications by both HIV-infected and uninfected persons. Designing the optimal package of interventions that matches the epidemiologic profile of a target population, delivering that package at the population level, and evaluating safety, acceptability, coverage, and effectiveness, all involve methodological challenges. Nonetheless, there is an unprecedented opportunity to develop “prevention packages” that combine various arrays of evidence-based strategies, tailored to the needs of diverse subgroups and targeted to achieve high coverage for a measurable reduction in population-level HIV transmission. HIV prevention strategies that combine partially effective interventions should be scaled up and evaluated.


Combination HIV prevention HIV prevention methods HIV prevention packages Antiretroviral therapy Test and treat 



Sources of support: This review was supported by NIH: NICHD grant 1R01 HD058363 (Kurth), NIAID 1RO1AI083034 (Celum, Baeten, Kurth, Wasserheit), and NIAID U01AI068619 (Vermund).


No potential conflicts of interest relevant to this article were reported.


Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ann E. Kurth
    • 1
    • 3
    Email author
  • Connie Celum
    • 2
    • 3
  • Jared M. Baeten
    • 2
    • 3
  • Sten H. Vermund
    • 4
    • 5
  • Judith N. Wasserheit
    • 2
    • 3
  1. 1.New York University College of NursingNew YorkUSA
  2. 2.Department of MedicineUniversity of WashingtonSeattleUSA
  3. 3.Department of Global HealthUniversity of WashingtonSeattleUSA
  4. 4.Vanderbilt Institute for Global HealthVanderbilt University School of MedicineNashvilleUSA
  5. 5.Department of PediatricsVanderbilt University School of MedicineNashvilleUSA

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