Current HIV/AIDS Reports

, Volume 7, Issue 1, pp 44–51 | Cite as

Antiretroviral Adherence Interventions: Translating Research Findings to the Real World Clinic

  • Jane M. SimoniEmail author
  • K. Rivet Amico
  • Laramie Smith
  • Kimberly Nelson


The success of potent combination antiretroviral therapy (ART) for HIV infection is compromised primarily by failure to maintain optimal levels of adherence over the long term. Recent reviews suggest behavioral interventions to promote ART adherence can have significant effects, but these tend to be small and to diminish over time; sustained improvements in biomarkers are particularly elusive. In this article, we update current reviews, focusing specifically on the 13 studies evaluating behavioral interventions to promote ART adherence published since September 2007. We describe the range of intervention strategies employed and qualitatively summarize findings of their efficacy. In conclusion, we consider implications and offer strategies for enhancing adherence in clinic-based HIV care prior to ART initiation, at initiation, and over the course of treatment.


HIV/AIDS ART Adherence Interventions Review 



No potential conflicts of interest relevant to this article were reported.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jane M. Simoni
    • 1
    Email author
  • K. Rivet Amico
    • 2
  • Laramie Smith
    • 3
  • Kimberly Nelson
    • 4
  1. 1.Department of PsychologyUniversity of WashingtonSeattleUSA
  2. 2.Center for Health, Intervention & PreventionUniversity of ConnecticutStorrsUSA
  3. 3.Center for Health, Intervention & Prevention, Department of PsychologyUniversity of ConnecticutStorrsUSA
  4. 4.Department of PsychologyUniversity of WashingtonSeattleUSA

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