Current HIV/AIDS Reports

, Volume 5, Issue 1, pp 20–26 | Cite as

Regulatory T cells in HIV infection: Who’s suppressing what?

Article

Abstract

The role of regulatory T cells (Treg) in HIV pathogenesis is not fully elucidated. Persistent antigens, such as HIV, are believed to promote the expansion and activation of antigen-specific Treg, and several reports have described beneficial and detrimental roles for Treg in HIV pathogenesis. These apparently contradictory observations may arise from imprecision in enumerating Treg and the lack of definition of Treg subsets. New markers allowing more precise identification and purification of Treg for functional studies have been described recently, and these may open avenues for efficient isolation of pure, homogenous populations of human Treg.

Keywords

Foxp3 Expression Treg Function Foxp3 mRNA Treg Number Treg Subset 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  1. 1.Centre for ImmunologySt Vincent’s HospitalDarlinghurstAustralia

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