Current Hepatology Reports

, Volume 17, Issue 3, pp 225–234 | Cite as

DILI Associated with Skin Reactions

  • Sahand Rahnama-Moghadam
  • Hans L. Tillmann
Drug-Induced Liver Injury (NP Chalasani and MS Ghabril, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Drug-Induced Liver Injury


Purpose of Review

Adverse drug reactions (ADR) frequently involve the liver and skin in the form of drug-induced liver injury or cutaneous drug eruption.

Recent Findings

Skin ADR can range from harmless rash to severe skin manifestations such as drug rash with eosinophilia and systemic symptom syndrome (DRESS syndrome), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP), all of which can be associated with severe outcome, including a 30% mortality rate in case of TEN. The association with co-occurring liver injury varies and in DRESS and SJS/TEN can contribute to substantial morbidity and mortality.


Liver and skin ADR are frequent but rarely severe; however, if severe, they are not uncommonly fatal.


Adverse drug reaction Drug-induced liver injury (DILI) Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS syndrome) Stevens-Johnson syndrome (SJS) Toxic epidermal necrolysis (TEN) Acute generalized exanthematous pustulosis (AGEP) 


Compliance with Ethical Standards

Conflict of Interest

Sahand Rahnama-Moghadam declares no conflicts of interest. Hans L. Tillmann reports that his spouse is a full-time employee of AbbVie; reports grants from NIH-NIDDK, during the conduct of the study; reports personal fees from AbbVie, Abbott, and Gilead for stocks; and reports personal fees from Novartis and Novo Nordisk for consulting, outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of DermatologyIndiana University School of MedicineIndianapolisUSA
  2. 2.Division of GastroenterologyEast Carolina UniversityGreenvilleUSA

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