Current Hepatitis Reports

, Volume 11, Issue 2, pp 95–101

Update on the Management of HBV-HDV Coinfection

  • Heiner Wedemeyer
  • Svenja Hardtke
  • Michael P. Manns
Hepatitis B: Therapeutics (P Martin, Section Editor)


Hepatitis Delta is caused by coinfection with the hepatitis B virus and the hepatitis D virus and has to be considered as the most severe form of viral hepatitis. HDV infection may affect between 15 and 20 Million individuals worldwide with significant regional differences of HDV prevalence rates. The diagnosis of hepatitis delta in HBsAg-positive individuals is based on the detection of HDV antibodies and HDV RNA. Interferon alpha remains the only effective treatment as currently available nucleoside or nucleotide analogous are not effective against HDV. Recent trials showed that about 25 % of HDV-infected patients may clear HDV RNA by therapy with pegylated interferon alpha. Liver transplantation remains the only treatment option for the majority patients with advanced liver disease


HDV Treatment Liver disease Epidemiology 


Papers of particular interest, published recently, have been highlighted as:• Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Heiner Wedemeyer
    • 1
  • Svenja Hardtke
    • 1
  • Michael P. Manns
    • 1
  1. 1.Department of Gastroenterology, Hepatology and EndocrinologyHannover Medical SchoolHannoverGermany

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