Current Hepatitis Reports

, Volume 10, Issue 1, pp 11–18

Extrahepatic Manifestations of Hepatitis C Virus Infection: Mixed Cryoglobulinemia and Beyond



Hepatitis C virus (HCV) is the most common blood-borne infection in the United States and is a leading cause of chronic liver disease worldwide. Extrahepatic manifestations of HCV infection occur frequently and are important to recognize as well as understand if they improve with antiviral therapy. This review summarizes the extrahepatic manifestations of HCV with particular emphasis on their degree of association and available treatment options.


Hepatitis C virus Chronic hepatitis C Extrahepatic manifestations Cryoglobulinemia Necrolytic acral erythema Lichen planus Chronic lymphocytic sialadenitis Glomerulonephritis Interferon Ribavirin Rituximab Autoimmune hemolytic anemia 

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2010

Authors and Affiliations

  1. 1.Gastroenterology Service, Department of MedicineWalter Reed Army Medical CenterWashingtonUSA

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