Treatment-Free Remission in CML: the US Perspective

  • Guru Subramanian Guru MurthyEmail author
  • Ehab Atallah
Chronic Myeloid Leukemias (M Mauro, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Chronic Myeloid Leukemias


Purpose of Review

Chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKI) have near-normal life expectancy. However, lifelong TKI therapy is associated with reduced quality of life and significant economic burden. Currently, the management of CML is shifting from continuous TKI therapy towards the goal of TKI cessation which is discussed in this review.

Recent Findings

Several studies in the last decade have demonstrated the feasibility and safety of TKI discontinuation in selected patients with CML who achieve deep and sustained molecular response with TKI. This has moved prime-time into clinical practice although open questions remain in terms of understanding the disease biology that leads to successful TKI cessation in some patients while not in others.


Cessation of TKI for CML patients is a feasible approach. Ongoing research aims to find out optimal strategies to sustain ongoing treatment-free remission (TFR) and increase the number of patients who achieve TFR.


Leukemia Myeloid Chronic Treatment Discontinuation 


Compliance with Ethical Standards

Conflict of Interest

Ehab Atallah reports personal fees from Novartis, BMS, and Pfizer, outside the submitted work. Guru Subramanian Guru Murthy declares no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Hematology/OncologyMedical College of WisconsinMilwaukeeUSA

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