Health-Related Quality of Life and Treatment of Older Adults with Acute Myeloid Leukemia: a Young International Society of Geriatric Oncology Review Paper
Purpose of Review
The treatment landscape for older patients with acute myeloid leukemia (AML) is evolving. Many treatments have comparable efficacy making their impact on quality of life (QoL) an important differentiating factor. In this review, we discuss QoL in older adults with AML, focusing on therapeutic and observational trials that have incorporated QoL assessments.
Health-related quality of life (HRQoL) is a multi-dimensional concept incorporating physical, mental, emotional, and social functioning domains. HRQoL components overlap with components of geriatric assessment, a multidisciplinary diagnostic process that identifies underlying vulnerabilities of older adults and guides subsequent management strategies. HRQoL questionnaires may be general, cancer-specific, leukemia-specific, or symptom-focused. Therapeutic and observational cohort studies suggest HRQoL improves, or at least remains stable, during intensive and lower-intensity therapies. Nonetheless, HRQoL is not routinely incorporated in AML therapeutic trials.
HRQoL assessments can inform both decision-making and management for older adults with AML.
KeywordsAcute myeloid leukemia Quality of life Geriatric assessment Therapeutic trials Intensive therapies Lower intensity therapies
We would like to thank Susan Rosenthal, MD for her editorial assistance. Dr. Loh is supported by the National Cancer Institute (K99CA237744) and Wilmot Research Fellowship Award.
Compliance with Ethical Standards
Conflict of Interest
Dr. Neuendorff declares travel support from Jazz Pharmaceuticals and advisory work for Janssen outside of the submitted work. Dr. Loh services as a consultant to Pfizer and Seattle Genetics. Dr. Kumar, Dr. Klepin, and Dr. Abdallah declare no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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