Current Hematologic Malignancy Reports

, Volume 13, Issue 6, pp 417–425 | Cite as

Bispecific Antibodies for the Treatment of Acute Myeloid Leukemia

  • Daniel G. Guy
  • Geoffrey L. UyEmail author
Acute Myeloid Leukemias (H Erba, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Acute Myeloid Leukemias


Purpose of review

Bispecific antibodies combine antigen recognition sites from two or more antibodies into a single construct allowing simultaneous binding to multiple targets. Bispecific antibodies exist which can redirect immune effector cells against acute myeloid leukemia (AML) targets. This review will highlight the progress to date and the challenges in developing bispecific antibodies for the treatment of AML.

Recent findings

Currently, a number of bispecific antibody formats including bispecific T cell engagers, dual affinity retargeting proteins, and tandem diabodies are in clinical development for AML. These antibodies target antigens present on AML blasts, including CD33, and the low affinity IL3 receptor, CD123. T cell redirecting bispecific antibodies in early phase clinical trials for AML include AG330, flotetuzumab, JNJ-63709178, and AMV564.


Bispecific antibodies represent a promising immunotherapeutic approach for the treatment of cancer. The results of ongoing studies in AML will elucidate the potential for these agents in AML.


Acute myeloid leukemia Bispecific antibody Dual affinity retargeting protein Bispecific T cell engager 


Compliance with Ethical Standards

Conflict of Interest

Geoffrey Uy reports personal fees from Glycomimetics, personal fees from Pfizer, personal fees from Curis, personal fees from Jazz, and personal fees from Novartis, outside the submitted work. Daniel Guy declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of OncologyWashington University School of MedicineSt. LouisUSA

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