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Current Hematologic Malignancy Reports

, Volume 12, Issue 4, pp 282–289 | Cite as

An Update on the Use of Immunotherapy in the Treatment of Lymphoma

  • Thomas U. Marron
  • Matko Kalac
  • Joshua Brody
B-cell NHL, T-cell NHL, and Hodgkin Lymphoma (D Persky, Section Editor)
Part of the following topical collections:
  1. Topical Collection on B-cell NHL, T-cell NHL, and Hodgkin Lymphoma

Abstract

Purpose of Review

Throughout the field of oncology, immunotherapy is moving further towards the first-line setting, and there is encouraging data for the use of these novel therapies in the management of lymphomas, utilizing treatments approved for both solid and hematologic malignancies. Herein, we review promising advances in this rapidly moving field from the past year.

Recent Findings

In the last year, we have seen promising clinical data on engineered antibody therapies for the treatment of lymphomas, as well as further optimization of engineered antibody fragments fused onto linkers or chimeric T cell receptors, both of the modalities capable of transforming non-specific T cells into tumor-specific, serial killer cells.

Summary

Here we will review the promising data on these advances in antibody-based therapies, as well as some of the immunomodulators and checkpoint-blocking therapies that shown to have promising results in the treatment of lymphomas within the past year.

Keywords

Lymphoma immunotherapy 

Notes

Compliance with Ethical Standards

Conflict of Interest

Thomas U Marron, Matko Kalac, and Joshua Brody each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article contains no studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Department of Medicine, Division of Hematology and OncologyIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Department of Medicine, Division of Hematology and OncologyColumbia University Medical CenterNew YorkUSA

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