CARs in the Lead Against Multiple Myeloma
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The recent clinical success of CD19-directed chimeric antigen receptor (CAR) T cell therapy in chronic and acute leukemia has led to increased interest in broadening this technology to other hematological malignancies and solid tumors. Now, advances are being made using CAR T cell technology to target myeloma antigens such as B cell maturation antigen (BCMA), CD138, and kappa-light chain as well as CD19 on putative myeloma stem cells. To date, only a limited number of multiple myeloma patients have received CAR T cell therapy but preliminary results have been encouraging. In this review, we summarize the recently reported results of clinical trials conducted utilizing CAR T cell therapy in multiple myeloma (MM).
KeywordsChimeric antigen receptor Multiple myeloma B cell maturation antigen Adoptive T cell therapy Clinical trials
Autologous stem cell transplant
Chimeric antigen receptor
Chronic lymphocytic leukemia
Acute lymphoblastic leukemia
Single-chain variable fragment
Cytokine release syndrome
Posterior reversible encephalopathy syndrome
Polymerase chain reaction
B cell maturation antigen
American Society of Hematology
Very good partial response
Non Hodgkin’s lymphoma
Compliance with Ethical Standards
Conflict of Interest
Maria Ormhøj declares no potential conflicts of interest.
Felipe Bedoya reports a patent pending.
Matthew J. Frigault reports a patent issued and royalties received for compositions and methods for generating a persisting population of T cells useful for the treatment of cancer.
Marcela V. Maus reports a patent pending with some licensed to Novartis for a portfolio relevant to the use of CAR T cells in general, and to multiple myeloma specifically, including CD19.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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