Current Hematologic Malignancy Reports

, Volume 11, Issue 3, pp 196–207 | Cite as

Allogeneic Stem Cell Transplantation for Non-Hodgkin Lymphoma

  • Vijaya Raj Bhatt
B-cell NHL, T-cell NHL, and Hodgkin Lymphoma (J Armitage, Section Editor)
Part of the following topical collections:
  1. Topical Collection on B-cell NHL, T-cell NHL, and Hodgkin Lymphoma


Observational studies indicate a similar or higher probability of disease control, higher risk of non-relapse mortality (NRM), and similar overall survival (OS) with allogeneic stem cell transplantation (alloSCT), compared to autologous SCT, in relapsed or refractory non-Hodgkin lymphoma. Careful patient selection and utilization of reduced intensity conditioning (RIC) alloSCT may allow reduction in NRM. The optimal conditioning regimen and the roles of radioimmunotherapy, T cell depletion, and tandem SCT continue to be explored. Recent studies highlight comparable results with haploidentical SCT and cord blood SCT, thus providing alternate donor sources. Disease relapse and late effects continue to be major problems. Optimization of SCT techniques (e.g., improved graft-versus-host disease prophylaxis), post-transplant monitoring of minimal residual disease, and post-transplant maintenance, or pre-emptive therapy (e.g., with novel therapies) are emerging strategies to reduce the risk of relapse. Survivorship management using a multidisciplinary care approach, adoption of healthy lifestyle, and socioeconomic counseling are integral parts of a high-quality transplant program.


Non-Hodgkin lymphoma Diffuse large B cell lymphoma Follicular lymphoma Mantle cell lymphoma Peripheral T cell lymphoma Autologous stem cell transplantation Allogeneic stem cell transplantation 



This work was supported by the University of Nebraska Medical Center, College of Medicine, Physician-Scientist Training Program Grant 2015–2016.

Compliance with Ethical Standards

Conflict of Interest

The author declares that he has no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of Hematology-OncologyUniversity of Nebraska Medical CenterOmahaUSA

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