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Current Hematologic Malignancy Reports

, Volume 10, Issue 2, pp 112–117 | Cite as

Secondary Acute Myeloid Leukemias Arising From Philadelphia Chromosome Negative Myeloproliferative Neoplasms: Pathogenesis, Risk Factors, and Therapeutic Strategies

  • Michael Tallarico
  • Olatoyosi Odenike
Acute Myeloid Leukemias (R Stone, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Acute Myeloid Leukemias

Abstract

The classic Philadelphia chromosome negative myeloproliferative neoplasms including primary myelofibrosis, polycythemia vera, and essential thrombocythemia are associated with a variable propensity for transformation into acute myeloid leukemia. Leukemic transformation in these disorders, so called MPN-blast phase, is uniformly associated with a poor prognosis. In recent years, there has been an increasing understanding of the molecular complexity underlying Philadelphia chromosome negative myeloproliferative neoplasms (Ph− MPNs), and this has spurred efforts to investigate the molecular risk factors associated with clinical outcome in these disorders, including the risk of leukemic transformation. At the same time, there is an ongoing and significant need for new approaches which have the potential to change the natural history of these disorders. This review will focus on the risk factors associated with the development of MPN in blast phase (MPN-BP) including clinical and molecular risk factors, current treatment strategies, and emerging investigational approaches.

Keywords

Secondary AML MPN-blast phase Leukemic transformation Philadelphia chromosome negative MPN Primary myelofibrosis Polycythemia vera 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Dr. Michael Tallarico declares no potential conflict of interest.

Dr. Olatoyosi Odenike reports grants paid to her institution for clinical research from Eisai; Lily, Novartis, NS-Pharma, S*Bio, Incyte, Gilead, MEI-Pharma, Topotarget, Astex, Celgene, Geron, Sunesis, Spectrum, Sanofi; personal fees for advisory board participation from Sunesis, Spectrum, Sanofi, Incyte and Algeta.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Medicine, Section of Hematology/OncologyThe University of ChicagoChicagoUSA
  2. 2.The Comprehensive Cancer CenterThe University of ChicagoChicagoUSA

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