Current Hematologic Malignancy Reports

, Volume 8, Issue 4, pp 299–306

Genetic Basis of MPN: Beyond JAK2-V617F

Myeloproliferative Disorders (JJ Kiladjian, Section Editor)

Abstract

The clonal blood disorders polycythemia vera, essential thrombocythemia and primary myelofibrosis belong to the BCR-ABL1-negative myeloproliferative neoplasms and are specified by increased production of terminally differentiated myeloid cells. Clonal evolution, disease initiation and progression are influenced by genetic alterations, often affecting cytokine signaling and gene expression. This review outlines somatic changes discovered in myeloproliferative neoplasms and how these genetic aberrations influence the pathogenesis of myeloproliferative neoplasms. Furthermore, genetic responses to drug treatments in myeloproliferative neoplasms are discussed.

Keywords

Myeloproliferative neoplasms JAK2 Clonal evolution Oncogene Tumor suppressor Hematologic malignancy 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.CeMM Research Center for Molecular Medicine of the Austrian Academy of SciencesViennaAustria
  2. 2.Department of Internal Medicine IMedical University of ViennaViennaAustria

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