Current Hematologic Malignancy Reports

, Volume 5, Issue 3, pp 148–156 | Cite as

Gemcitabine and Other New Cytotoxic Drugs: Will Any Find Their Way Into Primary Therapy?



Primary treatment for classic Hodgkin lymphoma (HL) remains highly effective with chemotherapy alone or combined-modality therapy. The limitations of therapy have been related to toxicity and efficacy in subsets of patients. The introduction of a number of new and novel cytotoxic agents has provided opportunities for investigating their use in the treatment of HL. This article briefly reviews current primary treatment strategies for HL and examines the existing data for both new cytotoxic agents and other selected novel agents in the treatment of HL.


Hodgkin Gemcitabine Vinorelbine Rituximab Bendamustine Lenalidomide Panobinostat SGN-35 


Acknowledgments and Disclosure

Dr. Friedberg is a Scholar in Clinical Research of the Leukemia and Lymphoma Society and is supported, in part, by the University of Rochester SPORE in Lymphoma (CA-130805). He is a member of a Data and Safety Monitoring Board sponsored by Eli Lilly, and previously served on an advisory board for Seattle Genetics. No other potential conflicts of interest relevant to this article were reported.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.James P. Wilmot Cancer Center, Division of Hematology/OncologyUniversity of Rochester Medical CenterRochesterUSA

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