Is Hodgkin lymphoma just another B-cell lymphoma?
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Hodgkin disease was the first defined lymphoid neoplasm. For many decades it was regarded as a disease separate from non-Hodgkin lymphoma. However, recent studies have shown that the dysplastic cells of Hodgkin lymphoma (HL) are monoclonal B cells. This finding raised again the question “Is HL just another B-cell lymphoma?” This article reviews the different aspects of HL and B-cell non-Hodgkin lymphoma (B-NHL), concluding that—despite the same cell of origin—fundamental differences exist in morphology, cellular composition, immunophenotype, activation or inhibition of transcription factors, epigenetics, and clinical behavior. These findings lead us to conclude that HL and B-NHLs should stay as two separate categories.
KeywordsHodgkin Lymphoma Hodgkin Disease Classic Hodgkin Lymphoma Dysplastic Cell Nodular Lymphocyte Predominant Hodgkin Lymphoma
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