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Current Hematologic Malignancy Reports

, Volume 1, Issue 4, pp 220–229 | Cite as

The role of rituximab in autologous and allogeneic hematopoietic stem cell transplantation for non-Hodgkin’s lymphoma

  • Elizabeth NaparstekEmail author
Article

Abstract

The addition of rituximab to chemotherapy has substantially changed the treatment strategies for patients with B-cell lymphomas. Rituximab, combined with standard chemotherapy regimens, shows consistently improved results compared with chemotherapy alone and has been extensively employed in both newly diagnosed and relapsed patients with B-cell lymphoma. Because of its low toxicity profile and its potent antilymphoma activity mediated through direct apoptotic and indirect effector mechanisms, rituximab also has been actively incorporated into stem cell transplantation (SCT) protocols to attain a state of minimal disease, provide a safe and effective method for in vivo purging prior to autologous SCT, and promote graft-versus-lymphoma effects in allogeneic SCT. This review compiles the still immature but rapidly growing data on this combined modality.

Keywords

Overall Survival Stem Cell Transplantation Follicular Lymphoma Mantle Cell Lymphoma Autologous Stem Cell Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Current Science Inc 2006

Authors and Affiliations

  1. 1.Department of Hematology and BMT, Tel Aviv Sourasky Medical Center, Sackler Faculty of MedicineTel Aviv UniversityTel-AvivIsrael

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