Current Heart Failure Reports

, Volume 16, Issue 5, pp 150–156 | Cite as

Updates on Heart Transplantation

  • Kevin S. Shah
  • Michelle M. Kittleson
  • Jon A. Kobashigawa
Updates in Advanced Heart Failure (E. Rame and M. St. John Sutton, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Updates in Advanced Heart Failure


Purpose of Review

The purpose of this review is to provide a comprehensive update on recent advances in heart transplantation.

Recent Findings

Heart transplantation is now an established therapy for end-stage heart failure, though challenges still exist. However, multiple advances over the past few years will improve the survival and quality of life of heart transplant recipients. These advances include acceptance of previously considered marginal donor hearts, revisions to the donor heart allocation policy, advances in desensitization regimens, tailoring of immunosuppression regimens, and improvement in the diagnosis of rejection and allograft vasculopathy.


Heart transplantation is evolving to provide better quality of life and survival to higher risk recipients with methods to broaden the donor pool, make the best use of existing organs, and refine the management of sensitization and diagnosis of rejection and allograft vasculopathy.


Heart transplant Allocation Mechanical circulatory support Allograft rejection Surveillance Endomyocardial biopsy 


Compliance with Ethical Standards

Conflict of Interest

Kevin S. Shah and Michelle M. Kittleson declare no conflicts of interest. Jon A. Kobashigawa reports grants from Novartis, grants from Alexion, grants and personal fees from CareDx, grants from Sanofi, all outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Kevin S. Shah
    • 1
  • Michelle M. Kittleson
    • 1
  • Jon A. Kobashigawa
    • 1
  1. 1.Cedars-Sinai Smidt Heart InstituteLos AngelesUSA

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