Current Heart Failure Reports

, Volume 15, Issue 5, pp 281–286 | Cite as

Clinical Implications of Serum Biomarkers of Cardiac Stress in Aortic Stenosis

  • Nimesh Patel
  • Dharam J. KumbhaniEmail author
Biomarkers of Heart Failure (W Tang and J Grodin, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Biomarkers of Heart Failure


Purpose of Review

The purpose of this review is to outline the relationship between serum biomarkers of cardiac stress and the pathophysiologic progression of aortic stenosis, to identify studies exploring the utility of biomarkers in the risk stratification and management of patients with aortic stenosis, and to highlight the biomarkers most practical to management of patients with aortic stenosis.

Recent Findings

Several biomarkers have been identified that reflect various aspects of the pathogenesis of calcific aortic stenosis, subsequent hemodynamic obstruction leading to myocardial remodeling, oxidative stress and injury, and concomitant systemic inflammation. These markers are associated with adverse outcomes in aortic stenosis and offer incremental value in risk prediction over traditional clinical assessment for aortic stenosis. NTproBNP and troponin are the most rigorously studied serum biomarkers in aortic stenosis, and only NTproBNP is currently reflected in any major guideline on aortic stenosis management.


Serum biomarkers show promise in guiding management of aortic stenosis, but still require significant prospective investigation before they can be incorporated in major guidelines.


Serum biomarkers Heart failure Aortic stenosis 


Compliance with Ethical Standards

Conflict of Interest

Nimesh Patel declares no potential conflicts of interest.

Dharam J. Kumbhani reports honoraria from the American College of Cardiology.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of CardiologyUniversity of Texas Southwestern Medical CenterDallasUSA

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