Current Heart Failure Reports

, Volume 11, Issue 2, pp 156–165

Heart Failure and Obesity in Adults: Pathophysiology, Clinical Manifestations and Management

  • Martin A. Alpert
  • Harsh Agrawal
  • Kul Aggarwal
  • Senthil A. Kumar
  • Arun Kumar
Pathophysiology: Neuroendocrine, Vascular, and Metabolic Factors (SD Katz, Section Editor)


Obesity is both a risk factor and a direct cause of heart failure (HF) in adults. Severe obesity produces hemodynamic alterations that predispose to changes in left ventricular morphology and function, which, over time, may lend to the development of HF (obesity cardiomyopathy). Certain neurohormonal and metabolic abnormalities as well as cardiovascular co-morbidities may facilitate this process. Substantial purposeful weight loss is capable of reversing most of the alterations in cardiac performance and morphology and may improve functional capacity and quality of life in patents with obesity cardiomyopathy.


Obesity Severe obesity Obesity cardiomyopathy Heart failure Epidemiology Pathophysiology Risk factor Obesity paradox Central hemodynamics Left ventricular mass Left ventricular hypertrophy Left ventricular diastolic chamber size Left ventricular geometry Concentric and eccentric hypertrophy Left ventricular diastolic dysfunction Left ventricular systolic dysfunction Tissue Doppler imaging Neurohormonal and metabolic alterations Systemic hypertension Clinical manifestations Medical therapy Weight loss 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Martin A. Alpert
    • 1
  • Harsh Agrawal
    • 1
  • Kul Aggarwal
    • 1
  • Senthil A. Kumar
    • 1
  • Arun Kumar
    • 1
  1. 1.University-Columbia Division of Cardiovascular MedicineUniversity of Missouri Health Sciences CenterColumbiaUSA

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