Current Heart Failure Reports

, Volume 10, Issue 1, pp 89–100 | Cite as

Impact of Adverse Events on Ventricular Assist Device Outcomes

  • Aleksandar Adzic
  • Snehal R. Patel
  • Simon Maybaum
Nonpharmacologic Therapy: Surgery, Ventricular Assist Devices, Biventricular Pacing, and Exercise (AK Hasan, Section Editor)

Abstract

Left ventricular assist devices have been proven to be superior to medical therapy for advanced heart failure patients awaiting heart transplantation and viable alternatives to transplantation for destination therapy patients. Improvements in the design of ventricular assist devices have been rewarded by a decrease in adverse events and an increase in survival. Despite significant progress, even the latest generation left ventricular assist devices are burdened by a significant long-term adverse events profile that will increasingly challenge physicians as patients survive longer on implantable mechanical circulatory support. In this review, we analyze the impact of long-term adverse events on clinical outcomes in the major trials of continuous flow left ventricular assist devices. We discuss several of the more pertinent and interesting adverse events, examine their potential causes, and explore their future implications.

Keywords

Left ventricular assist device(s) Adverse events Continuous-flow Device malfunction Pump thrombosis Stroke Infection Gastrointestinal bleeding Aortic insufficiency 

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Aleksandar Adzic
    • 1
  • Snehal R. Patel
    • 1
  • Simon Maybaum
    • 2
  1. 1.Division of CardiologyMontefiore Medical CenterBronxUSA
  2. 2.Albert Einstein College of MedicineBronxUSA

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