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Current Heart Failure Reports

, Volume 9, Issue 2, pp 117–127 | Cite as

Chemotherapy-Induced Cardiotoxicity

  • Amir Y. Shaikh
  • Jeffrey A. ShihEmail author
Management of Heart Failure (T Meyer, Section Editor)

Abstract

Anthracycline-based chemotherapeutics have long been recognized as effective agents for treating a wide range of malignancies. However, their use is not without significant adverse cardiotoxic side effects. Strategies for prevention involve limiting free-radical production and subsequent cardiac myocyte damage. Dexrazoxane remains the most widely studied cardioprotective medication. Alternative agents may reduce cardiotoxicity but may still cause significant cardiovascular problems. The role of β-blockers and angiotensin-converting enzyme inhibitors in the treatment of heart failure is well proven. The role of these medications in the prevention and treatment of chemotherapy-induced cardiotoxicity is not well established.

Keywords

Doxorubicin Anthracycline Trastuzumab Heart failure Cardiomyopathy Chemotherapy Management Tyrosine kinase inhibitors TKIs Cardiotoxicity Cardio-oncology 

Notes

Disclosures

No potential conflicts of interest relevant to this article were reported.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.University of Massachusetts Memorial Medical CenterWorcesterUSA

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