Current Heart Failure Reports

, Volume 8, Issue 2, pp 131–139

Androgen Deficiency in Heart Failure

  • Gülmisal Güder
  • Bruno Allolio
  • Christiane E. Angermann
  • Stefan Störk
Article

DOI: 10.1007/s11897-011-0053-9

Cite this article as:
Güder, G., Allolio, B., Angermann, C.E. et al. Curr Heart Fail Rep (2011) 8: 131. doi:10.1007/s11897-011-0053-9

Abstract

Androgen deficiency is a hormonal disorder that is frequently observed in advanced chronic conditions. A reduction of androgen blood levels may be cause or consequence of the disease, or both. Typical symptoms, such as fatigue or muscle weakness, may be particularly aggravated in heart failure, and disease severity may be indirectly affected by low levels of androgen. Recently, androgen replacement therapy has been suggested as a new treatment option of heart failure symptoms, and placebo-controlled pilot trials showed a modest improvement of physical performance. However, testosterone replacement in elderly patients is not without risks, and the benefit–risk ratio for such adjunct treatment is unclear. This review focuses on the general effects of androgens on the cardiovascular system and outlines expected benefits and suspected side effects of testosterone replacement therapy in patients with heart failure.

Keywords

Androgen deficiency Testosterone replacement therapy Heart failure 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Gülmisal Güder
    • 1
    • 2
  • Bruno Allolio
    • 1
    • 2
  • Christiane E. Angermann
    • 1
    • 2
  • Stefan Störk
    • 1
    • 2
  1. 1.Department of Internal Medicine IUniversity Hospital WürzburgWürzburgGermany
  2. 2.Comprehensive Heart Failure CenterUniversity of WürzburgWürzburgGermany

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