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Current Heart Failure Reports

, Volume 7, Issue 4, pp 202–211 | Cite as

Right Ventricular Failure: A Novel Era of Targeted Therapy

  • Dipanjan Banerjee
  • Francois Haddad
  • Roham T. Zamanian
  • Jayan Nagendran
Article

Abstract

There now is strong evidence to recognize the pivotal role of the right ventricle (RV) in heart disease and to establish it as a unique and separate entity than the left ventricle (LV). Here, we summarize the differences between the two ventricles, the diagnosis of RV failure, and the management of acute and chronic RV failure. We review the indices derived by echocardiography used to measure RV function, and novel biomarkers that may play a role diagnosing and prognosticating in RV-specific disease. There are new novel therapies that specifically target the RV in disease. For example, phosphodiesterase type 5 inhibitors improve contractility of the hypertrophied RV while sparing the normal LV in pulmonary arterial hypertension. The metabolism of the hypertrophied RV is another area for therapeutic exploitation by metabolic modulation. We also suggest future potential molecular targets that may be unique to the RV because they are upregulated in RV hypertrophy greater than in LV hypertrophy.

Keywords

Heart failure Right ventricle Hypertrophy Biomarkers Therapy 

Notes

Disclosures

D. Banerjee: none; F. Haddad: none; R. T. Zamanian serves as a consultant for United Therapeutics and Gilead, has received a research grant from the Wall Center for Pulmonary Vascular Disease and the Entelligence Young Investigator Award, and has received payment for developing the Simply Speaking Education Program for pulmonary arterial hypertension; J. Nagendran: none.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Dipanjan Banerjee
    • 1
  • Francois Haddad
    • 1
  • Roham T. Zamanian
    • 2
  • Jayan Nagendran
    • 3
  1. 1.Division of Cardiovascular MedicineStanford University School of MedicineStanfordUSA
  2. 2.Division of Pulmonary and Critical Care Medicine, Vera Moulton Wall Center for Pulmonary Vascular DiseaseStanford School of MedicineStanfordUSA
  3. 3.Department of Cardiothoracic SurgeryStanford University School of MedicineStanfordUSA

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