Current Heart Failure Reports

, Volume 5, Issue 1, pp 51–55 | Cite as

Future directions in cardiac resynchronization therapy

  • Cecilia LindeEmail author


Cardiac resynchronization therapy (CRT) reduces symptoms and improves mortality in patients with moderate to severe chronic heart failure (New York Heart Association class III–IV) in sinus rhythm with reduced left ventricular ejection fraction and with wide QRS on the surface electrocardiogram as evidence of ventricular dyssynchrony. CRT’s benefit in patients with atrial fibrillation, mild heart failure, or a conventional indication for antibradycardia pacing is being assessed. Moreover, the PROSPECT trial assessed whether the response rate to CRT might increase if, in addition to wide QRS, mechanical dyssynchrony criteria were required. The RethinQ study examined whether patients with narrow QRS but with mechanical dyssynchrony benefit from CRT. Finally, whether patients with heart failure with preserved left ventricular function also may benefit from CRT remains to be studied.


Left Ventricular Ejection Fraction Chronic Heart Failure Heart Failure With Preserve Ejection Fraction Ventricular Assist Device Reverse Remodel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Department of CardiologyKarolinska University HospitalSolnaSweden

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