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Technical Aspects of Fecal Microbial Transplantation (FMT)

  • N. Bhutiani
  • J. E. Schucht
  • K. R. Miller
  • Stephen A. McClave
Nutrition and Obesity (S McClave, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Nutrition and Obesity

Abstract

Purpose of Review

Fecal microbial transplantation (FMT) has become established as an effective therapeutic modality in the treatment of antibiotic-refractory recurrent Clostridium difficile colitis. A number of formulations and methods of delivery of FMT are currently available, each with distinct advantages. This review aims to review donor and patient selection for FMT as well as procedural aspects of FMT to help guide clinical practice.

Recent Findings

FMT can be obtained in fresh, frozen, lyophilized, and capsule-based formulations for delivery by oral ingestion, nasoenteric tube, colonoscopy, or enema (depending on the formulation used). Choosing the optimal method relies heavily on patient-related factors, including underlying pathology and severity of illness. As potential applications for FMT expand, careful donor screening and patient selection are critical to minimizing risk to patients and physicians.

Summary

FMT represents an excellent therapeutic option for treatment of recurrent Clostridium difficile colitis and holds promise as a possible treatment modality in a variety of other conditions. The wide array of delivery methods allows for its application in various disease states in both the inpatient and outpatient setting.

Keywords

Fecal transplant Dysbiosis 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. Bhutiani
    • 1
  • J. E. Schucht
    • 1
  • K. R. Miller
    • 1
  • Stephen A. McClave
    • 2
  1. 1.Department of Surgery, Division of Trauma and Critical CareUniversity of LouisvilleLouisvilleUSA
  2. 2.Department of Medicine, Division of GastroenterologyUniversity of LouisvilleLouisvilleUSA

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